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Unfortunately, the antibody (ID:151550) is no longer available.

Below is a list of antibodies to the same protein target. You may also try your search again using the search box at the top of the page. Please contact us if you have any questions.



NPC / NPC1

Niemann-Pick disease, type C1

Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Both NPC1 and NPC2 function as the cellular 'tag team duo' (TTD) to catalyze the mobilization of cholesterol within the multivesicular environment of the late endosome (LE) to effect egress through the limiting bilayer of the LE. NPC2 binds unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes and transfers it to the cholesterol-binding pocket of the N-terminal domain of NPC1. Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket and is exported from the limiting membrane of late endosomes/ lysosomes to the ER and plasma membrane by an unknown mechanism. Binds oxysterol with higher affinity than cholesterol. May play a role in vesicular trafficking in glia, a process that may be crucial for maintaining the structural and functional integrity of nerve terminals.

Gene Name: Niemann-Pick disease, type C1
Synonyms: NPC1, NPC, Niemann-Pick C1 protein, Niemann-Pick disease, type C1
Target Sequences: NM_000271

Publications (18)

1
Niemann-pick type C1 (NPC1) overexpression alters cellular cholesterol homeostasis. Millard EE, Srivastava K, Traub LM, Schaffer JE, Ory DS. The Journal of biological chemistry. 2000 275:38445-51. (ICC, WB) [PubMed:10964915]
2
Cholesterol overload promotes morphogenesis of a Niemann-Pick C (NPC)-like compartment independent of inhibition of NPC1 or HE1/NPC2 function. Frolov A, Srivastava K, Daphna-Iken D, Traub LM, Schaffer JE, Ory DS. The Journal of biological chemistry. 2001 276:46414-21. (ICC) [PubMed:11571306]
3
Purified NPC1 protein. I. Binding of cholesterol and oxysterols to a 1278-amino acid membrane protein. Infante RE, Abi-Mosleh L, Radhakrishnan A, Dale JD, Brown MS, Goldstein JL. The Journal of biological chemistry. 2008 283:1052-63. (WB; Human) [PubMed:17989073]
4
Niemann-Pick type C1 I1061T mutant encodes a functional protein that is selected for endoplasmic reticulum-associated degradation due to protein misfolding. Gelsthorpe ME, Baumann N, Millard E, Gale SE, Langmade SJ, Schaffer JE, Ory DS. The Journal of biological chemistry. 2008 283:8229-36. (IP) [PubMed:18216017] [PMC:PMC2276376]
5
Transport of maternal cholesterol to the fetus is affected by maternal plasma cholesterol concentrations in the golden Syrian hamster. Burke KT, Colvin PL, Myatt L, Graf GA, Schroeder F, Woollett LA. Journal of lipid research. 2009 50:1146-55. [PubMed:19122238] [PMC:PMC2681396]
6
NPC1 repression contributes to lipid accumulation in human macrophages exposed to environmental aryl hydrocarbons. Podechard N, Le Ferrec E, Rebillard A, Fardel O, Lecureur V. Cardiovascular research. 2009 82:361-70. [PubMed:19131362]
7
Cholesterol sensor ORP1L contacts the ER protein VAP to control Rab7-RILP-p150 Glued and late endosome positioning. Rocha N, Kuijl C, van der Kant R, Janssen L, Houben D, Janssen H, Zwart W, Neefjes J. The Journal of cell biology. 2009 185:1209-25. [PubMed:19564404] [PMC:PMC2712958]
8
Cyclodextrin overcomes deficient lysosome-to-endoplasmic reticulum transport of cholesterol in Niemann-Pick type C cells. Abi-Mosleh L, Infante RE, Radhakrishnan A, Goldstein JL, Brown MS. Proceedings of the National Academy of Sciences of the United States of America. 2009 106:19316-21. [PubMed:19884502] [PMC:PMC2780767]
9
MLN64 mediates egress of cholesterol from endosomes to mitochondria in the absence of functional Niemann-Pick Type C1 protein. Charman M, Kennedy BE, Osborne N, Karten B. Journal of lipid research. 2010 51:1023-34. (WB; Mouse) [PubMed:19965586] [PMC:PMC2853429]
10
FTY720 stimulates 27-hydroxycholesterol production and confers atheroprotective effects in human primary macrophages. Blom T, Bck N, Mutka AL, Bittman R, Li Z, de Lera A, Kovanen PT, Diczfalusy U, Ikonen E. Circulation research. 2010 106:720-9. [PubMed:20056921] [PMC:PMC2871287]
11
Anatomically defined neuron-based rescue of neurodegenerative Niemann-Pick type C disorder. Lopez ME, Klein AD, Dimbil UJ, Scott MP. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2011 31:4367-78. [PubMed:21430138] [PMC:PMC3071647]
12
Imaging the impact of Nox4 in cycling hypoxia-mediated U87 glioblastoma invasion and infiltration. Hsieh CH, Chang HT, Shen WC, Shyu WC, Liu RS. Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging. 2012 14:489-99. (IHC; Mouse) [PubMed:21870211]
13
Amiodarone impairs trafficking through late endosomes inducing a Niemann-Pick C-like phenotype. Piccoli E, Nadai M, Caretta CM, Bergonzini V, Del Vecchio C, Ha HR, Bigler L, Dal Zoppo D, Faggin E, Pettenazzo A, Orlando R, Salata C, Calistri A, Pal G, Baritussio A. Biochemical pharmacology. 2011 82:1234-49. [PubMed:21878321]
14
A novel role for -tocopherol transfer protein (-TTP) in protecting against chloroquine toxicity. Shichiri M, Kono N, Shimanaka Y, Tanito M, Rotzoll DE, Yoshida Y, Hagihara Y, Tamai H, Arai H. The Journal of biological chemistry. 2012 287:2926-34. (WB; Rat) [PubMed:22147702] [PMC:PMC3268449]
15
Subversion of NPC1 pathway of cholesterol transport by Anaplasma phagocytophilum. Xiong Q, Rikihisa Y. Cellular microbiology. 2012 14:560-76. (ICC) [PubMed:22212234] [PMC:PMC3604884]
16
Loss of Niemann Pick type C proteins 1 and 2 greatly enhances HIV infectivity and is associated with accumulation of HIV Gag and cholesterol in late endosomes/lysosomes. Coleman EM, Walker TN, Hildreth JE. Virology journal. 2012 9:31. [PubMed:22273177] [PMC:PMC3299633]
17
Tracking sphingosine metabolism and transport in sphingolipidoses: NPC1 deficiency as a test case. Blom T, Li Z, Bittman R, Somerharju P, Ikonen E. Traffic (Copenhagen, Denmark). 2012 13:1234-43. (WB; Human) [PubMed:22607065]
18
An essential role of Hrs/Vps27 in endosomal cholesterol trafficking. Du X, Kazim AS, Brown AJ, Yang H. Cell reports. 2012 1:29-35. (WB; Human) [PubMed:22832105]
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Target Reactivity Applications Host Isotype Clonality Clone Format Epitope Publications Type
NPC / NPC1 Mouse IgG1 Monoclonal Unconjugated,HRP Conjugated,Biotin Conjugated,FITC Conjugated,AP Conjugated,APC Conjugated,PE Conjugated Human IHC-P, IF, WB, IP,IF, WB,IF, WB,IF, WB,IF, WB,IF, WB,IF, WB
7
NPC / NPC1 Mouse IgG1 Monoclonal Unconjugated Human IHC-P, IF, WB, IP No Primary
Anti-NPC / NPC1 Antibody IHC-plus™ LS-B3437
Immunohistochemistry Image
Immunohistochemistry Image


Mouse Monoclonal (IgG1) to Human NPC / NPC1
Human
IHC - Paraffin, Immunofluorescence, Western blot, Immunoprecipitation
Unconjugated
NPC / NPC1 Mouse IgG1 Monoclonal HRP Conjugated Human IF, WB No Primary
Anti-NPC / NPC1 Antibody (HRP) LS-C548427


Mouse Monoclonal (IgG1) to Human NPC / NPC1
Human
Immunofluorescence, Western blot
HRP Conjugated
NPC / NPC1 Mouse IgG1 Monoclonal Biotin Conjugated Human IF, WB No Primary
Anti-NPC / NPC1 Antibody (Biotin) LS-C528326


Mouse Monoclonal (IgG1) to Human NPC / NPC1
Human
Immunofluorescence, Western blot
Biotin Conjugated
NPC / NPC1 Mouse IgG1 Monoclonal FITC Conjugated Human IF, WB No Primary
Anti-NPC / NPC1 Antibody (FITC) LS-C538284


Mouse Monoclonal (IgG1) to Human NPC / NPC1
Human
Immunofluorescence, Western blot
FITC Conjugated
NPC / NPC1 Mouse IgG1 Monoclonal AP Conjugated Human IF, WB No Primary
Anti-NPC / NPC1 Antibody (AP) LS-C510285


Mouse Monoclonal (IgG1) to Human NPC / NPC1
Human
Immunofluorescence, Western blot
AP Conjugated
NPC / NPC1 Mouse IgG1 Monoclonal APC Conjugated Human IF, WB No Primary
Anti-NPC / NPC1 Antibody (APC) LS-C518443


Mouse Monoclonal (IgG1) to Human NPC / NPC1
Human
Immunofluorescence, Western blot
APC Conjugated
NPC / NPC1 Mouse IgG1 Monoclonal PE Conjugated Human IF, WB No Primary
Anti-NPC / NPC1 Antibody (PE) LS-C656447


Mouse Monoclonal (IgG1) to Human NPC / NPC1
Human
Immunofluorescence, Western blot
PE Conjugated
NPC / NPC1 Rabbit Polyclonal Unconjugated,Biotin Conjugated,DY550 Conjugated,DY488 Conjugated,DY650 Conjugated Human, Mouse, Hamster, Primate IHC-P, IF, WB, IP,IHC, IHC-P, IF, WB, IP,IHC, IHC-P, IF, WB, IP,IHC, IHC-P, IF, WB, IP,IHC, IHC-P, IF, WB, IP C-Terminus
5
NPC / NPC1 Rabbit Polyclonal Unconjugated Human, Mouse, Hamster, Primate IHC-P, IF, WB, IP C-Terminus No Primary
Anti-NPC / NPC1 Antibody (C-Terminus) IHC-plus™ LS-B509
Immunohistochemistry Image


Rabbit Polyclonal to Human NPC / NPC1
Human, Mouse, Hamster, Primate
IHC - Paraffin, Immunofluorescence, Western blot, Immunoprecipitation
Unconjugated
NPC / NPC1 Rabbit Polyclonal Biotin Conjugated Human, Mouse, Hamster IHC, IHC-P, IF, WB, IP C-Terminus No Primary
Anti-NPC / NPC1 Antibody (C-Terminus, Biotin) LS-C142211
Immunohistochemistry Image
Western blot Image


Rabbit Polyclonal to Human NPC / NPC1
Human, Mouse, Hamster
IHC, IHC - Paraffin, Immunofluorescence, Western blot, Immunoprecipitation
Biotin Conjugated
NPC / NPC1 Rabbit Polyclonal DY550 Conjugated Human, Mouse, Hamster IHC, IHC-P, IF, WB, IP C-Terminus No Primary
Anti-NPC / NPC1 Antibody (C-Terminus, DY550) LS-C142215
Immunohistochemistry Image
Western blot Image


Rabbit Polyclonal to Human NPC / NPC1
Human, Mouse, Hamster
IHC, IHC - Paraffin, Immunofluorescence, Western blot, Immunoprecipitation
DY550 Conjugated
NPC / NPC1 Rabbit Polyclonal DY488 Conjugated Human, Mouse IHC, IHC-P, IF, WB, IP C-Terminus No Primary
Anti-NPC / NPC1 Antibody (C-Terminus, DY488) LS-C142213
Immunohistochemistry Image
Western blot Image


Rabbit Polyclonal to Human NPC / NPC1
Human, Mouse
IHC, IHC - Paraffin, Immunofluorescence, Western blot, Immunoprecipitation
DY488 Conjugated
NPC / NPC1 Rabbit Polyclonal DY650 Conjugated Human, Mouse, Hamster IHC, IHC-P, IF, WB, IP C-Terminus No Primary
Anti-NPC / NPC1 Antibody (C-Terminus, DY650) LS-C142212
Immunohistochemistry Image
Western blot Image


Rabbit Polyclonal to Human NPC / NPC1
Human, Mouse, Hamster
IHC, IHC - Paraffin, Immunofluorescence, Western blot, Immunoprecipitation
DY650 Conjugated
NPC / NPC1 Mouse IgG1 Monoclonal 8D10B6 Unconjugated Human IHC-P, WB, ELISA aa34-174
1
NPC / NPC1 Mouse IgG1 Monoclonal 8D10B6 Unconjugated Human IHC-P, WB, ELISA aa34-174 No Primary
Anti-NPC / NPC1 Antibody (aa34-174, clone 8D10B6) LS-C285835
Immunohistochemistry Image
Immunohistochemistry Image


Mouse Monoclonal [clone 8D10B6] (IgG1) to Human NPC / NPC1
Human
IHC - Paraffin, Western blot, ELISA
Unconjugated
NPC / NPC1 Rabbit Polyclonal Unconjugated Human IHC-P, IF, WB aa591-620
1
NPC / NPC1 Rabbit Polyclonal Unconjugated Human IHC-P, IF, WB aa591-620 No Primary Available
Anti-NPC / NPC1 Antibody (aa591-620) LS-C162956
Immunohistochemistry Image
Immunofluorescence Image


Rabbit Polyclonal to Human NPC / NPC1
Human
IHC - Paraffin, Immunofluorescence, Western blot
Unconjugated
NPC / NPC1 Rabbit Polyclonal Unconjugated Human, Mouse IHC-P, WB, ELISA C-Terminus
1
NPC / NPC1 Rabbit Polyclonal Unconjugated Human, Mouse IHC-P, WB, ELISA C-Terminus No Primary Available
Anti-NPC / NPC1 Antibody (C-Terminus) IHC-plus™ LS-B6977
Immunohistochemistry Image
Immunohistochemistry Image


Rabbit Polyclonal to Human NPC / NPC1
Human, Mouse
IHC - Paraffin, Western blot, ELISA
Unconjugated
NPC / NPC1 Mouse IgG2a,k Monoclonal 4H2 Unconjugated Human IHC-P, WB, ELISA
1
NPC / NPC1 Mouse IgG2a,k Monoclonal 4H2 Unconjugated Human IHC-P, WB, ELISA No Primary
Anti-NPC / NPC1 Antibody (clone 4H2) IHC-plus™ LS-B13046
Immunohistochemistry - Paraffin Image
Immunohistochemistry - Paraffin Image


Mouse Monoclonal [clone 4H2] (IgG2a,k) to Human NPC / NPC1
Human
IHC - Paraffin, Western blot, ELISA
Unconjugated
NPC / NPC1 Goat Polyclonal Unconjugated Mouse ELISA aa1039-1052
1
NPC / NPC1 Goat Polyclonal Unconjugated Mouse ELISA aa1039-1052 No Primary Available
Anti-NPC / NPC1 Antibody (aa1039-1052) LS-C113011


Goat Polyclonal to Mouse NPC / NPC1
Mouse
ELISA
Unconjugated
NPC / NPC1 Rabbit IgG Polyclonal Unconjugated,HRP Conjugated,Biotin Conjugated,FITC Conjugated,PE Conjugated,AP Conjugated,APC Conjugated Human IHC, IF, WB, ELISA,IHC, WB, ELISA,IHC, IF, WB, ELISA,IHC, ICC, IF, WB, ELISA,IHC, ICC, IF, WB, ELISA,IHC, ICC, IF, WB, ELISA,IHC, ICC, IF, WB, ELISA aa590-620
7
NPC / NPC1 Rabbit IgG Polyclonal Unconjugated Human IHC, IF, WB, ELISA aa590-620 No Primary
Anti-NPC / NPC1 Antibody (aa590-620) LS-C323410


Rabbit Polyclonal (IgG) to Human NPC / NPC1
Human
IHC, Immunofluorescence, Western blot, ELISA
Unconjugated
NPC / NPC1 Rabbit IgG Polyclonal HRP Conjugated Human IHC, WB, ELISA No Primary
Anti-NPC / NPC1 Antibody (HRP) LS-C540546


Rabbit Polyclonal (IgG) to Human NPC / NPC1
Human
IHC, Western blot, ELISA
HRP Conjugated
NPC / NPC1 Rabbit IgG Polyclonal Biotin Conjugated Human IHC, IF, WB, ELISA No Primary
Anti-NPC / NPC1 Antibody (Biotin) LS-C520394


Rabbit Polyclonal (IgG) to Human NPC / NPC1
Human
IHC, Immunofluorescence, Western blot, ELISA
Biotin Conjugated
NPC / NPC1 Rabbit IgG Polyclonal FITC Conjugated Human IHC, ICC, IF, WB, ELISA aa591-620 No Primary
Anti-NPC / NPC1 Antibody (aa591-620, FITC) LS-C264604


Rabbit Polyclonal (IgG) to Human NPC / NPC1
Human
IHC, ICC, Immunofluorescence, Western blot, ELISA
FITC Conjugated
NPC / NPC1 Rabbit IgG Polyclonal PE Conjugated Human IHC, ICC, IF, WB, ELISA aa591-620 No Primary
Anti-NPC / NPC1 Antibody (aa591-620, PE) LS-C264605


Rabbit Polyclonal (IgG) to Human NPC / NPC1
Human
IHC, ICC, Immunofluorescence, Western blot, ELISA
PE Conjugated
NPC / NPC1 Rabbit IgG Polyclonal AP Conjugated Human IHC, ICC, IF, WB, ELISA aa591-620 No Primary
Anti-NPC / NPC1 Antibody (aa591-620, AP) LS-C264601


Rabbit Polyclonal (IgG) to Human NPC / NPC1
Human
IHC, ICC, Immunofluorescence, Western blot, ELISA
AP Conjugated
NPC / NPC1 Rabbit IgG Polyclonal APC Conjugated Human IHC, ICC, IF, WB, ELISA aa591-620 No Primary
Anti-NPC / NPC1 Antibody (aa591-620, APC) LS-C264603


Rabbit Polyclonal (IgG) to Human NPC / NPC1
Human
IHC, ICC, Immunofluorescence, Western blot, ELISA
APC Conjugated
NPC / NPC1 Rabbit Polyclonal Unconjugated Human, Mouse IHC, IF, WB, IP C-Terminus
1
NPC / NPC1 Rabbit Polyclonal Unconjugated Human, Mouse IHC, IF, WB, IP C-Terminus No Primary
Anti-NPC / NPC1 Antibody (C-Terminus) LS-C73562


Rabbit Polyclonal to Human NPC / NPC1
Human, Mouse
IHC, Immunofluorescence, Western blot, Immunoprecipitation
Unconjugated
NPC / NPC1 Rabbit IgG Polyclonal Unconjugated Human IHC, ELISA
1
NPC / NPC1 Rabbit IgG Polyclonal Unconjugated Human IHC, ELISA No Primary
Anti-NPC / NPC1 Antibody LS-C406623
Immunohistochemistry Image


Rabbit Polyclonal (IgG) to Human NPC / NPC1
Human
IHC, ELISA
Unconjugated
NPC / NPC1 Rabbit Polyclonal Unconjugated Human
1
NPC / NPC1 Rabbit Polyclonal Unconjugated Human No Primary
Anti-NPC / NPC1 Antibody LS-C488502


Rabbit Polyclonal to Human NPC / NPC1
Human
Unconjugated
Target Corresponding Antibodies
NPC / NPC1
1
NPC / NPC1 Antibody Blocking Peptide - LS-E2450

LS-E2450
NPC / NPC1
LS-C162956
NPC / NPC1
1
NPC / NPC1 Antibody Blocking Peptide - LS-E27388

LS-E27388
NPC / NPC1
LS-C113011
NPC / NPC1
1
NPC / NPC1 Antibody Blocking Peptide - LS-E30708

LS-E30708
NPC / NPC1
LS-B6977
Type Target Tag Species Source Purified Biological Activity Known Endotoxin Level Animal-Free
NPC / NPC1 None Human Human Purified Known endotoxin level
1
Human NPC / NPC1 Protein (Arg372-Phe622) - LS-G51420


Human HEK 293 Cells
None
Purified / Lyophilized / Endotoxin Level: Less than 1.0 EU/µg protein (determined by LAL method).
Arg372-Phe622
Selected:

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).


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