NOX4

NADPH oxidase 4

Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation. Isoform 3 is not functional. Isoform 5 and isoform 6 display reduced activity.Isoform 4: Involved in redox signaling in vascular cells. Constitutively and NADPH-dependently generates reactive oxygen species (ROS). Modulates the nuclear activation of ERK1/2 and the ELK1 transcription factor, and is capable of inducing nuclear DNA damage. Displays an increased activity relative to isoform 1.

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Products

Proteins (8)

Type

Over-Expression Lysate (2)

Recombinant (6)

Target

NOX4 (8)

Publications

No (8)

Tag

6His, N-terminus (1)

6His-B2M, N-terminus (1)

GST, N-terminus (1)

His (1)

His, N-Terminal (1)

His-SUMO (1)

Myc-DDK (Flag) (2)

Species

Human (5)

Rat (2)

Source

293T Cells (1)

E. coli (4)

HEK 293 Cells (1)

Wheat Germ Extract (1)

Yeast (1)

Purification

Purified (2)

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Human NOX4 Protein (Recombinant GST, N-terminus) (aa479-578) - LS-G62365

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

2 µg/$439

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Rat NOX4 Protein (Recombinant 6His-B2M, N-terminus) (aa210-424) - LS-G56426

Source:

E. coli

Tag:

6His-B2M, N-terminus

Price:

1 mg/$1,679; 100 µg/$598; 20 µg/$405

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Human NOX4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G84243

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

66.7 kDa

Price:

20 µg/$150

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Human NOX4 Protein (Recombinant His) (aa220-392) - LS-G14468

Source:

E. coli

Tag:

His

Molecular Weight:

21.5 kDa

Price:

10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119

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Rat NOX4 Protein (Recombinant His-SUMO) (aa210-424) - LS-G23057

Source:

Yeast

Tag:

His-SUMO

Molecular Weight:

40.6 kD

Price:

100 µg/$499; 20 µg/$364; 1 mg/$1,683

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Human NOX4 Protein (Recombinant 6His, N-terminus) - LS-G137073

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

28.8 kDa

Price:

20 µg/$364; 1 mg/$1,679; 100 µg/$500

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Human NOX4 Protein (Recombinant His, N-Terminal) (Leu446-Ser578) - LS-G133003

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

19.8kDa

Price:

10 µg/$267; 50 µg/$352; 200 µg/$702; 100 µg/$562; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900

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NOX4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G101468

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

66.7 kDa

Price:

100 µg/$494

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