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Transcription regulator acting downstream of both FOXA2 and T during notochord development. Required for node morphogenesis. Is essential for cilia formation in the posterior notochord (PNC) and for left-right patterning; acts upstream of FOXJ1 and RFX3 in this process and is required for the expression of various components important for axonemal assembly and function. Plays a role in regulating axial versus paraxial cell fate.
Gene Name: | notochord homeobox |
Synonyms: | NOTO, Notochord homeobox, Notochord homolog, Homeobox protein notochord |
Target Sequences: | NM_001134462 NP_001007473.1 Q5TIS6 |
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