NOTCH4

notch 4

NOTCH4 is a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. This gene may be associated with susceptibility to schizophrenia in a small portion of cases. An alternative splice variant has been described but its biological nature has not been determined.

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Proteins (4)

Type

Over-Expression Lysate (2)

Recombinant (2)

Target

NOTCH4 (4)

Publications

No (4)

Tag

His-T7 (2)

Myc-DDK (Flag) (2)

Species

Human (2)

Rat (1)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (1)

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Human NOTCH4 Protein (Recombinant His-T7) (aa1715-2001) - LS-G16109

Source:

E. coli

Tag:

His-T7

Molecular Weight:

33.3 kDa

Price:

10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119

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Human NOTCH4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G80944

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

210.1 kDa

Price:

20 µg/$215

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Rat NOTCH4 Protein (Recombinant His-T7) (aa1690-1945) - LS-G16114

Source:

E. coli

Tag:

His-T7

Molecular Weight:

30.7 kDa

Price:

10 µg/$287; 50 µg/$480; 100 µg/$767; 200 µg/$957; 1 mg/$2,089; 500 µg/$1,617; 5 mg/$3,347; 2 mg/$2,278

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NOTCH4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100328

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

210.1 kDa

Price:

100 µg/$710

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