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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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NOTCH4

notch 4

NOTCH4 is a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. This gene may be associated with susceptibility to schizophrenia in a small portion of cases. An alternative splice variant has been described but its biological nature has not been determined.

Gene Name: notch 4
Synonyms: NOTCH4, HNotch4, Notch (Drosophila) homolog 4, Notch homolog 4 (Drosophila), Notch homolog 4, INT3, Notch 4
Target Sequences: NM_004557 NP_004548.3 Q99466

Publications (7)

1
Differential expression of Notch receptors and their ligands in desmoplastic ameloblastoma. Siar CH, Nakano K, Han PP, Nagatsuka H, Ng KH, Kawakami T. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology. 2010 39:552-8. (IHC-P; Human) [PubMed:20337864]
2
Notch4 overexpression in ameloblastoma correlates with the solid/multicystic phenotype. Siar CH, Nagatsuka H, Chuah KS, Rivera RS, Nakano K, Ng KH, Kawakami T. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics. 2010 110:224-33. (IHC-P; Human) [PubMed:20659700]
3
Immunolocalization of notch signaling protein molecules in a maxillary chondrosarcoma and its recurrent tumor. Siar CH, Ha KO, Aung LO, Nakano K, Tsujigiwa H, Nagatsuka H, Ng KH, Kawakami T. European journal of medical research. 2010 15:456-60. (IHC-P; Human) [Full Text Article] [PubMed:21156405] [PMC:PMC3352190]
4
Notch signaling and ghost cell fate in the calcifying cystic odontogenic tumor. Siar CH, Kawakami T, Buery RR, Nakano K, Tomida M, Tsujigiwa H, Han PP, Nagatsuka H, Ng KH. European journal of medical research. 2011 16:501-6. (IHC-P; Human) [PubMed:22027644] [PMC:PMC3351808]
5
Notch receptors in human choroid plexus tumors. Beschorner R, Waidelich J, Trautmann K, Psaras T, Schittenhelm J. Histology and histopathology. Aug;28:1055-63. [Full Text Article] [PubMed:23479446] Related Antibodies: LS-B3498.
6
Notch signaling plays a critical role in motility and differentiation of human first-trimester cytotrophoblasts. Haider S, Meinhardt G, Velicky P, Otti GR, Whitley G, Fiala C, Pollheimer J, Kn[Character f6]fler M. Endocrinology. 2014 Jan;155:263-74. [Full Text Article] [PubMed:24189144] Related Antibodies: LS-C137135.
7
Notch2 controls prolactin and insulin-like growth factor binding protein-1 expression in decidualizing human stromal cells of early pregnancy. Otti GR, Saleh L, Velicky P, Fiala C, Pollheimer J, Knöfler M. PloS one. 2014 9:e112723. (IHC; Human) [Full Text Article] [PubMed:25397403] [PMC:PMC4232464] Related Antibodies: LS-C137135.
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Filtered By: None
Target
NOTCH4 (69)
Reactivity
Human (37)
Mouse (29)
Rat (24)
Bovine (8)
Chimpanzee (3)
Gibbon (3)
Guinea pig (4)
Horse (8)
Monkey (2)
Pig (7)
Application
IHC (27)
IHC-P (8)
WB (52)
Flo (12)
ELISA (7)
ICC (6)
IF (1)
IP (1)
Peptide-ELISA (3)
Host
rabbit (51)
mouse (1)
goat (2)
hamster (14)
rat (1)
Isotype
IgG (52)
IgG1 (1)
IgG2a (1)
Clonality
monoclonal mc (16)
polyclonal pc (53)
Clone
12G39 (1)
12G40 (1)
HMN4-14 (2)
L5C5 (1)
Format
AP Conjugated (3)
APC (2)
APC Conjugated (3)
Biotin Conjugated (10)
Cy3 Conjugated (2)
Cy7 Conjugated (2)
FITC Conjugated (10)
HRP Conjugated (8)
PE Conjugated (6)
Unconjugated (25)
Epitope
aa1690-1945 (10)
aa1715-2001 (10)
C-Terminus (7)
Internal (4)
aa371-420 (4)
aa1778-2003 (2)
1370-1450 aa, C-terminal (1)
aa1261-1273 (1)
aa1401-1450 (1)
aa1805-1818 (1)
aa1819-1851 (1)
aa1984-2002 (1)
aa5708-6217 (1)
Publications
No (67)
Yes (2)
Showing 1-25 of 69 results

NOTCH4 Antibody (aa371-420) IHC-plus™ LS-B3498
Publications (1)
Publications (1)
Rabbit Polyclonal (IgG) to Human NOTCH4
Guinea pig, Bovine, Pig, Horse, Human
IHC IHC-P WB
Unconjugated
50µg  $485.00
Anti-NOTCH4 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-NOTCH4 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-NOTCH4 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-NOTCH4 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

NOTCH4 Antibody (aa371-420, HRP) LS-C428440
Rabbit Polyclonal (IgG) to Human NOTCH4
Guinea pig, Bovine, Pig, Horse, Human, Chimpanzee
IHC IHC-P WB
HRP Conjugated
100µl 0.65mg/ml  $385.00
Anti-NOTCH4 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-NOTCH4 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-NOTCH4 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-NOTCH4 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

NOTCH4 Antibody (aa371-420, Biotin) LS-C428437
Rabbit Polyclonal (IgG) to Human NOTCH4
Guinea pig, Bovine, Pig, Horse, Human, Chimpanzee
IHC IHC-P WB
Biotin Conjugated
100µl 1mg/ml  $385.00
Anti-NOTCH4 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-NOTCH4 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-NOTCH4 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-NOTCH4 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

NOTCH4 Antibody (aa371-420, FITC) LS-C428438
Rabbit Polyclonal (IgG) to Human NOTCH4
Guinea pig, Bovine, Pig, Horse, Human, Chimpanzee
IHC IHC-P WB
FITC Conjugated
100µl 1mg/ml  $385.00
Anti-NOTCH4 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-NOTCH4 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-NOTCH4 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-NOTCH4 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

NOTCH4 Antibody (clone L5C5) IHC-plus™ LS-B7289
Mouse Monoclonal [clone L5C5] (IgG1) to Human NOTCH4
Human
ELISA IHC IHC-P IP WB
Unconjugated
50µl  $515.00
Anti-NOTCH4 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.
Anti-NOTCH4 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.

NOTCH4 Antibody (C-Terminus) LS-C137135
Publications (2)
Publications (2)
Rabbit Polyclonal (IgG) to Human NOTCH4
Human
ELISA IHC
Unconjugated
100µl 1mg/ml  $255.00
Immunohistochemistry Image
Immunohistochemistry Image

NOTCH4 Antibody (clone HMN4-14, PE) LS-C106197
Hamster Monoclonal [clone HMN4-14] (IgG) to Mouse NOTCH4
Mouse
Flo
PE Conjugated
25µg 0.2mg/ml  $245.00; 100µg 0.2mg/ml  $355.00
Staining of CD8+CD11c+-gated C57Bl/6 splenocytes with 0.25 ug of PE Armenian Hamster IgG isotype control (blue histogram) or 0.5 ug of PE anti-mouse Notch4 (HMN4-14) (purple histogram). Total viable cells were used for analysis. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Staining of CD8+CD11c+-gated C57Bl/6 splenocytes with 0.25 ug of PE Armenian Hamster IgG isotype control (blue histogram) or 0.5 ug of PE anti-mouse Notch4 (HMN4-14) (purple histogram). Total viable cells were used for analysis. This image was taken for the unconjugated form of this product. Other forms have not been tested.

NOTCH4 Antibody (clone HMN4-14) LS-C188665
Hamster Monoclonal [clone HMN4-14] (IgG) to Mouse NOTCH4
Mouse
Flo
Unconjugated
100µg 1mg/ml  $255.00

NOTCH4 Antibody (aa1261-1273) LS-C154837
Goat Polyclonal to Human NOTCH4
Mouse, Rat, Human
IF Peptide-ELISA
Unconjugated
100µg 0.5mg/ml  $335.00

NOTCH4 Antibody (aa5708-6217) LS-C91117
Rabbit Polyclonal (IgG) to Mouse NOTCH4
Mouse
WB
Unconjugated
200µg 1mg/ml  $605.00

NOTCH4 Antibody (clone 12G39) LS-C182625
Hamster Monoclonal [clone 12G39] (IgG) to Mouse NOTCH4
Mouse
Flo
Unconjugated
250µg 1mg/ml  $515.00

NOTCH4 Antibody (aa1778-2003) LS-C37775
Rat Monoclonal (IgG2a) to Human NOTCH4
Human
ELISA ICC WB
Unconjugated
100µg 100µl  $620.00

NOTCH4 Antibody LS-C402723
Rabbit Polyclonal (IgG) to Human NOTCH4
Human
ELISA IHC WB
Unconjugated
120µl 1mg/ml  $335.00
Immunohistochemistry of Human colon cancer using NOTCH4 Polyclonal Antibody at dilution of 1:30.
Western blot analysis of Human liver cancer and kidney tissue, using NOTCH4 Polyclonal Antibody at dilution of 1:500.
Immunohistochemistry of Human colon cancer using NOTCH4 Polyclonal Antibody at dilution of 1:30.
Western blot analysis of Human liver cancer and kidney tissue, using NOTCH4 Polyclonal Antibody at dilution of 1:500.

NOTCH4 Antibody (aa1778-2003) LS-C37776
Goat Polyclonal (IgG) to Human NOTCH4
Human
ELISA ICC WB
Unconjugated
100µg 100µl  $770.00

NOTCH4 Antibody (aa1715-2001) LS-C315015
Rabbit Polyclonal (IgG) to Human NOTCH4
Rat, Human
IHC WB
Unconjugated
20µl 0.5mg/ml  $205.00; 100µl 0.5mg/ml  $265.00; 200µl 0.5mg/ml  $315.00; 1ml 0.5mg/ml  $575.00; 10ml 0.5mg/ml  $2,295.00
Western blot of recombinant NOTCH4.
Western blot of recombinant NOTCH4.

NOTCH4 Antibody (aa1715-2001, HRP) LS-C714399
Rabbit Polyclonal (IgG) to Human NOTCH4
Rat, Human
IHC WB
HRP Conjugated
20µl  $215.00; 100µl  $295.00; 200µl  $355.00; 1ml  $740.00; 10ml  $2,985.00
Western blot of recombinant NOTCH4.
Western blot of recombinant NOTCH4.

NOTCH4 Antibody (aa1715-2001, Biotin) LS-C424964
Rabbit Polyclonal (IgG) to Human NOTCH4
Human
ICC WB
Biotin Conjugated
100µl 0.5mg/ml  $395.00

NOTCH4 Antibody (aa1715-2001, FITC) LS-C424965
Rabbit Polyclonal (IgG) to Human NOTCH4
Human
ICC WB
FITC Conjugated
100µl 0.5mg/ml  $415.00

NOTCH4 Antibody (aa1715-2001, FITC) LS-C696437
Rabbit Polyclonal (IgG) to Human NOTCH4
Rat, Human
IHC WB
FITC Conjugated
20µl  $215.00; 100µl  $285.00; 200µl  $345.00; 1ml  $695.00; 10ml  $2,760.00
Western blot of recombinant NOTCH4.
Western blot of recombinant NOTCH4.

NOTCH4 Antibody (aa1715-2001, Cy3) LS-C705388
Rabbit Polyclonal (IgG) to Human NOTCH4
Rat, Human
IHC WB
Cy3 Conjugated
20µl  $255.00; 100µl  $375.00; 200µl  $465.00; 1ml  $1,140.00; 10ml  $4,605.00
Western blot of recombinant NOTCH4.
Western blot of recombinant NOTCH4.

NOTCH4 Antibody LS-C405965
Rabbit Polyclonal (IgG) to Human NOTCH4
Human
ELISA IHC
Unconjugated
20µl  $205.00; 60µl  $235.00; 120µl  $295.00; 200µl  $395.00
Immunohistochemistry of Human tonsil using NOTCH4 Polyclonal Antibody at dilution of 1:30.
Immunohistochemistry of Human tonsil using NOTCH4 Polyclonal Antibody at dilution of 1:30.
Immunohistochemistry of Human tonsil using NOTCH4 Polyclonal Antibody at dilution of 1:30.
Immunohistochemistry of Human tonsil using NOTCH4 Polyclonal Antibody at dilution of 1:30.

NOTCH4 Antibody (Internal, HRP) LS-C427043
Rabbit Polyclonal to Human NOTCH4
Pig, Human
IHC IHC-P WB
HRP Conjugated
100µl 0.65mg/ml  $385.00
NOTCH4 antibody (5 ug/ml) was used in IHC to stain formalin-fixed, paraffin-embedded human colon, submucosal plexus, followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. This image was taken for the unconjugated form of this product. Other forms have not been tested.
NOTCH4 antibody Western Blot analysis of HepG2 cell lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
NOTCH4 antibody (5 ug/ml) was used in IHC to stain formalin-fixed, paraffin-embedded human colon, submucosal plexus, followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. This image was taken for the unconjugated form of this product. Other forms have not been tested.
NOTCH4 antibody Western Blot analysis of HepG2 cell lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

NOTCH4 Antibody (Internal, Biotin) LS-C427294
Rabbit Polyclonal to Human NOTCH4
Pig, Human
IHC IHC-P WB
Biotin Conjugated
100µl 1mg/ml  $385.00
NOTCH4 antibody (5 ug/ml) was used in IHC to stain formalin-fixed, paraffin-embedded human colon, submucosal plexus, followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. This image was taken for the unconjugated form of this product. Other forms have not been tested.
NOTCH4 antibody Western Blot analysis of HepG2 cell lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
NOTCH4 antibody (5 ug/ml) was used in IHC to stain formalin-fixed, paraffin-embedded human colon, submucosal plexus, followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. This image was taken for the unconjugated form of this product. Other forms have not been tested.
NOTCH4 antibody Western Blot analysis of HepG2 cell lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

NOTCH4 Antibody (Internal, FITC) LS-C427041
Rabbit Polyclonal to Human NOTCH4
Pig, Human
IHC IHC-P WB
FITC Conjugated
100µl 1mg/ml  $385.00
NOTCH4 antibody (5 ug/ml) was used in IHC to stain formalin-fixed, paraffin-embedded human colon, submucosal plexus, followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. This image was taken for the unconjugated form of this product. Other forms have not been tested.
NOTCH4 antibody Western Blot analysis of HepG2 cell lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
NOTCH4 antibody (5 ug/ml) was used in IHC to stain formalin-fixed, paraffin-embedded human colon, submucosal plexus, followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. This image was taken for the unconjugated form of this product. Other forms have not been tested.
NOTCH4 antibody Western Blot analysis of HepG2 cell lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

NOTCH4 Antibody (1370-1450 aa, C-terminal) LS-C380512
Rabbit Polyclonal (IgG) to Human NOTCH4
Human, Monkey
ELISA WB
Unconjugated
100µl 1mg/ml  $265.00
Western blot of Cleaved-Notch 4 (V1432) antibody
Western blot of Cleaved-Notch 4 (V1432) antibody
Showing 1-25 of 69 results

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For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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