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NOTCH3

notch 3

NOTCH3 is the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).

Gene Name: notch 3
Family/Subfamily: Fibronectin , not assigned-Fibronectin
Synonyms: NOTCH3, CASIL, CADASIL, Notch 3, Notch (Drosophila) homolog 3, Notch homolog 3, Notch homolog 3 (Drosophila)
Target Sequences: NM_000435 NP_000426.2 Q9UM47

Publications (2)

1
Notch4 overexpression in ameloblastoma correlates with the solid/multicystic phenotype. Siar CH, Nagatsuka H, Chuah KS, Rivera RS, Nakano K, Ng KH, Kawakami T. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics. 2010 110:224-33. (IHC-P; Human) [PubMed:20659700]
2
Notch signaling and ghost cell fate in the calcifying cystic odontogenic tumor. Siar CH, Kawakami T, Buery RR, Nakano K, Tomida M, Tsujigiwa H, Han PP, Nagatsuka H, Ng KH. European journal of medical research. 2011 16:501-6. (IHC-P; Human) [PubMed:22027644] [PMC:PMC3351808]

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Cell Lysates (2)
Plasma (4)
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NOTCH3 ELISA Kit
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Sandwich
96-Well Microplate
Human
0.05 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$672
NOTCH3 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
46.875 - 3000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
NOTCH3 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
NOTCH3 ELISA Kit
Select
Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$783
NOTCH3 ELISA Kit
Select
Custom
96-Well Strip Plate
Rat
Colorimetric - 450nm (TMB)
1 Plate/$783
NOTCH3 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
NOTCH3 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$902
NOTCH3 ELISA Kit
Select
Development Kit
Antibody Pair and Standard
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
500 Wells/$1,199; 1000 Wells/$1,773
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).