NOTCH1

notch 1

Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis. May enhance HIF1A function by sequestering HIF1AN away from HIF1A. Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury. Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO).

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Products

ELISA Kits (15)

Type

Custom (3)

Development Kit (2)

Sandwich (10)

Target

NOTCH1 (15)

Reactivity

Human (8)

Mouse (4)

Rat (3)

Product Group

DevKit DuoPlus (2)

Format

12 x 8-Well Microstrips (1)

96-Well Microplate (2)

96-Well Strip Plate (10)

Antibody Pair and Standard (2)

Publications

No (15)

Sample Type

Cell Culture Supernatants (5)

Cell Lysates (6)

Plasma (11)

Serum (11)

Tissue Homogenates (8)

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Mouse NOTCH1 (Sandwich ELISA) ELISA Kit - LS-F14664

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

78 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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Rat NOTCH1 (Custom ELISA) ELISA Kit - LS-F50413

Type:

Custom

Format:

96-Well Microplate

Reactivity:

Rat

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$672

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Mouse NOTCH1 (Sandwich ELISA) ELISA Kit - LS-F55195

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$854

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DevKit DuoPlus Human NOTCH1 ELISA Development Kit - LS-F71515

Type:

Development Kit

Format:

Antibody Pair and Standard

Reactivity:

Human

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

500 Wells/$1,120; 1000 Wells/$1,642

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DevKit DuoPlus Mouse NOTCH1 ELISA Development Kit - LS-F71527

Type:

Development Kit

Format:

Antibody Pair and Standard

Reactivity:

Mouse

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

500 Wells/$1,142; 1000 Wells/$1,679

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Human NOTCH1 (Sandwich ELISA) ELISA Kit - LS-F39967

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

62.5 - 4000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum

Price:

1 Plate/$795

Select

Human NOTCH1 (Custom ELISA) ELISA Kit - LS-F56851

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

78 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$958

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Rat NOTCH1 (Sandwich ELISA) ELISA Kit - LS-F55353

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$893

Select

Human NOTCH1 (Sandwich ELISA) ELISA Kit - LS-F55042

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$834

Select

Rat NOTCH1 (Custom ELISA) ELISA Kit - LS-F14665

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Rat

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

Select

Human NOTCH1 (Sandwich ELISA) ELISA Kit - LS-F34134

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

78 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Mouse NOTCH1 (Sandwich ELISA) ELISA Kit - LS-F32076

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

7.813 - 500 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Human NOTCH1 (Sandwich ELISA) ELISA Kit - LS-F12173

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

78 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

Select

Human NOTCH1 (Sandwich ELISA) ELISA Kit - LS-F167

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

20 - 7000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum

Price:

1 Plate/$588

Select

Human NOTCH1 (Sandwich ELISA) ELISA Kit - LS-F1005

Type:

Sandwich

Format:

12 x 8-Well Microstrips

Reactivity:

Human

Range:

79 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Plasma, Serum

Price:

1 Plate/$618

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