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NOS1 / nNOS

nitric oxide synthase 1 (neuronal)

NOS1 / nNOS belongs to the family of nitric oxide synthases, which synthesize nitric oxide from L-arginine. Nitric oxide is a reactive free radical, which acts as a biologic mediator in several processes, including neurotransmission, and antimicrobial and antitumoral activities. In the brain and peripheral nervous system, nitric oxide displays many properties of a neurotransmitter, and has been implicated in neurotoxicity associated with stroke and neurodegenerative diseases, neural regulation of smooth muscle, including peristalsis, and penile erection. This protein is ubiquitously expressed, with high level of expression in skeletal muscle. Multiple transcript variants that differ in the 5' UTR have been described for this gene but the full-length nature of these transcripts is not known. Additionally, alternatively spliced transcript variants encoding different isoforms (some testis-specific) have been found for this gene.

Gene Name: nitric oxide synthase 1 (neuronal)
Synonyms: NOS1, BNOS, Constitutive NOS, IHPS1, NNOS, NC-NOS, Nitric oxide synthase, brain, N-NOS, Neuronal NOS, NOS, NOS type I, Nos, type i
Target Sequences: NM_000620 NP_000611.1 P29475

Publications (4)

1
Senescent Cells Impair Erectile Function through Induction of Endothelial Dysfunction and Nerve Injury in Mice. Nishimatsu H, Suzuki E, Saito Y, Niimi A, Nomiya A, Fukuhara H, Kume H, Homma Y. PloS one. 2015 10:e0124129. (WB; Rat) [Full Text Article] [PubMed:25894557] [PMC:PMC4404101]
2
Neuromedin B Restores Erectile Function by Protecting the Cavernous Body and the Nitrergic Nerves from Injury in a Diabetic Rat Model. Nishimatsu H, Suzuki E, Saito Y, Niimi A, Nomiya A, Yamada D, Homma Y. PloS one. 2015 10:e0133874. (ICC, WB; Human, Rat) [Full Text Article] [PubMed:26207818] [PMC:PMC4514746]
3
PPARa induced NOS1 phosphorylation via PI3K/Akt in guinea pig antral mucous cells: NO-enhancement in Ca(2+)-regulated exocytosis. Tanaka S, Hosogi S, Sawabe Y, Shimamoto C, Matsumura H, Inui T, Marunaka Y, Nakahari T. Biomedical research (Tokyo, Japan). 2016 37:167-78. (WB; Human) [Full Text Article] [PubMed:27356604] Related Antibodies: LS-B3272.
4
PPAR alpha autocrine regulation of Ca2+-regulated exocytosis in guinea pig antral mucous cells: NO and cGMP accumulation. Tanaka S, Sugiyama N, Takahashi Y, Mantoku D, Sawabe Y, Kuwabara H, Nakano T, Shimamoto C, Matsumura H, Marunaka Y, Nakahari T. American journal of physiology. Gastrointestinal and liver physiology. Dec;307:G1169-79. [Full Text Article] [PubMed:25342048] Related Antibodies: LS-B3272.
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Antibodies (144)
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NOS1 / nNOS (144)
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NOS1 / nNOS Antibody - Anti-nNOS / NOS1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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Neuroscience
NOS1 / nNOS Rabbit anti-Human Polyclonal (aa1422-1433) Antibody
Rabbit, Mouse, Dog, Horse, Bat, Human, Monkey
ICC, IHC, IHC-P, IP, WB
Unconjugated
100 µl/$460
NOS1 / nNOS Antibody - Anti-NOS1 / nNOS antibody IHC staining of human small intestine, submucosal plexus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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NOS1 / nNOS Rabbit anti-Rat Polyclonal (N-Terminus) Antibody
Mouse, Rat, Human
ELISA, IHC, IHC-Fr, IHC-P, WB
Unconjugated
50 µg/$485
NOS1 / nNOS Antibody - Anti-NOS1 / nNOS antibody IHC staining of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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NOS1 / nNOS Rabbit anti-Human Polyclonal (aa818-867) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
NOS1 / nNOS Antibody - Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Neuroscience
NOS1 / nNOS Goat anti-Human Polyclonal (aa1457-1468) Antibody
Rabbit, Mouse, Dog, Horse, Bat, Human, Monkey
IF, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$460
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NOS1 / nNOS Rabbit anti-Human Polyclonal (pSer1417) Antibody
Rat, Human
WB
Unconjugated
100 µg/$872
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NOS1 / nNOS Sheep anti-Rat Polyclonal (aa1409-1429) Antibody
Rat
IHC, WB
Unconjugated
100 µl/$826
NOS1 / nNOS Antibody - 1:100 staining human liver carcinoma tissues by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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NOS1 / nNOS Rabbit anti-Human Polyclonal (pSer852) Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
NOS1 / nNOS Antibody - Western blot of n-NOS phosphorylation expression in A549 whole cell lysates,The lane on the left is treated with the antigen-specific peptide.
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NOS1 / nNOS Rabbit anti-Human Polyclonal (pSer852) Antibody
Mouse, Rat, Human
ICC, IF, IHC, WB
Unconjugated
50 µg/$305; 100 µg/$357
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NOS1 / nNOS Mouse anti-Rat Monoclonal (N-Terminus) Antibody
Rat
ELISA, IHC, IHC-P, IP, WB
Unconjugated
100 µg/$786
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NOS1 / nNOS Mouse anti-Rat Monoclonal (HRP) Antibody
Mouse, Rat, Human
ELISA, IHC, IP, WB
HRP Conjugated
100 µl/$1,017
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NOS1 / nNOS Mouse anti-Rat Monoclonal (FITC) Antibody
Mouse, Rat, Human
ELISA, IHC, IP, WB
FITC Conjugated
100 µl/$1,017
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NOS1 / nNOS Mouse anti-Rat Monoclonal (APC) Antibody
Mouse, Rat, Human
ELISA, IHC, IP, WB
APC Conjugated
100 µl/$1,017
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NOS1 / nNOS Mouse anti-Rat Monoclonal (PE) Antibody
Mouse, Rat, Human
ELISA, IHC, IP, WB
PE Conjugated
100 µl/$1,017
NOS1 / nNOS Antibody -  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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NOS1 / nNOS Rabbit anti-Human Polyclonal (aa1418-1434) Antibody
Rat, Human
IHC, IHC-P, WB
Unconjugated
100 µg/$380
NOS1 / nNOS Antibody - P-peptide - + Immunohistochemistry analysis of paraffin-embedded human brain tissue using n-NOS (Phospho-Ser852) antibody.
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NOS1 / nNOS Rabbit anti-Human Polyclonal (pSer852) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$357
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NOS1 / nNOS Rabbit anti-Human Polyclonal (aa724-739) Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$957
NOS1 / nNOS Antibody - Immunohistochemistry analysis of paraffin-embedded human brain, using n-NOS (Phospho-Ser852) Antibody. The picture on the right is blocked with the phospho peptide.
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NOS1 / nNOS Rabbit anti-Human Polyclonal (pSer852) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
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NOS1 / nNOS Rabbit anti-Human Polyclonal (790-870 aa) Antibody
Mouse, Rat, Human, Monkey
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
NOS1 / nNOS Antibody - Western blot of NOS1 antibody
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NOS1 / nNOS Rabbit anti-Human Polyclonal (790-870 aa) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
NOS1 / nNOS Antibody - Western blot of nNOS polyclonal antibody using whole cell extracts from (1) rat brain (BML-SW103), (2) mouse brain 10 ng recombinant rat bNOS. In lane (4) the antibody was preincubated with blocking control peptide. The nitrocellulose membrane was probed with antibody at 5 ug/ml. The secondary antibody was GAR-AP diluted 1/2000 and the blot was developed with BCIP/NBT.
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NOS1 / nNOS Rabbit anti-Human Polyclonal Antibody
Chicken, Mouse, Rat, Human
ELISA, ICC, IF, WB
Unconjugated
100 µg/$597
NOS1 / nNOS Antibody - Western Blot; Sample: Recombinant NOS1, Human.
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NOS1 / nNOS Rabbit anti-Human Polyclonal (aa1199-1399) (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$308; 200 µl/$350; 500 µl/$489; 1 ml/$558; 2 ml/$749; 5 ml/$1,217
NOS1 / nNOS Antibody - Immunofluorescent analysis of HepG2 cells using NOS1 Antibody at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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NOS1 / nNOS Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IF, WB
Unconjugated
50 µg/$294; 100 µg/$360
NOS1 / nNOS Antibody - Western blot of nNOS expression in INF treated RAW264.7 whole cell lysates,The lane on the left is treated with the antigen-specific peptide.
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NOS1 / nNOS Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ICC, IF, WB
Unconjugated
50 µg/$305; 100 µg/$357
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NOS1 / nNOS Rabbit anti-Human Polyclonal Antibody
Human
ELISA, ICC, WB
Unconjugated
100 µl/$587
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NOS1 / nNOS Rabbit anti-Human Polyclonal Antibody
Human
ELISA, ICC, WB
Unconjugated
50 µl/$717
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).