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NOP10
NOP10 ribonucleoprotein
Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ("psi") residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme.
| Gene Name: | NOP10 ribonucleoprotein |
| Synonyms: | NOP10, DKCB1, Homolog of yeast Nop10p, NOLA3, Nucleolar protein 10, SnoRNP protein NOP10, NOP10 ribonucleoprotein, NOP10P |
| Target Sequences: | NM_018648 NP_061118.1 Q9NPE3 |
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