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NMNAT1 / NMNAT
nicotinamide nucleotide adenylyltransferase 1
Catalyzes the formation of NAD+ from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD+. For the pyrophosphorolytic activity, prefers NAD+ and NAAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate (NHD) and nicotinamide guanine dinucleotide (NGD) less effectively. Fails to cleave phosphorylated dinucleotides NADP+, NADPH and NAADP+. Protects against axonal degeneration following mechanical or toxic insults.
| Gene Name: | nicotinamide nucleotide adenylyltransferase 1 |
| Synonyms: | NMNAT1, LCA9, NMN adenylyltransferase 1, NMNAT, PNAT1, NaMN adenylyltransferase 1 |
| Target Sequences: | NM_022787 NP_073624.2 Q9HAN9 |
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