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NKX6-1

NK6 homeobox 1

Transcription factor which binds to specific A/T-rich DNA sequences in the promoter regions of a number of genes. Involved in transcriptional regulation in islet beta cells. Binds to the insulin promoter and is involved in regulation of the insulin gene. Together with NKX2-2 and IRX3 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class II proteins of neuronal progenitor factors, which are induced by SHH signals.

Gene Name: NK6 homeobox 1
Synonyms: NKX6-1, NKX6A, NK homeobox, family 6, A, NK6 homeobox 1, Homeobox protein Nkx-6.1, NKX6.1
Target Sequences: NM_006168 NP_006159.2 P78426

Publications (4)

1
Decreased GLUT2 and glucose uptake contribute to insulin secretion defects in MODY3/HNF1A hiPSC-derived mutant ß cells. Blaise Su Jun Low, Chang Siang Lim , Shirley Suet Lee Ding , Yaw Sing Tan , Natasha Hui Jin Ng, Vidhya Gomathi Krishnan, Su Fen Ang, Claire Wen Ying Neo, Chandra S Verma, Shawn Hoon, Su Chi Lim, E Shyong Tai, Adrian Kee Keong Teo. Nature communications. 2021 May;12:3133. [Full Text Article] [PubMed:34035238] [PMC:PMC8149827] Related Antibodies: LS-C124275.
2
Differentiation of human pluripotent stem cells into two distinct NKX6.1 populations of pancreatic progenitors. Idil I Aigha, Bushra Memon, Ahmed K Elsayed, Essam M Abdelalim. Stem cell research & therapy. 2018 Apr;9:83. [Full Text Article] [PubMed:29615106] [PMC:PMC5883581] Related Antibodies: LS-C124275.
3
Pseudotemporal Ordering of Single Cells Reveals Metabolic Control of Postnatal ß Cell Proliferation. Chun Zeng, Francesca Mulas, Yinghui Sui, Tiffany Guan, Nathanael Miller, Yuliang Tan, Fenfen Liu, Wen Jin, Andrea C Carrano, Mark O Huising, Orian S Shirihai, Gene W Yeo, Maike Sander. Cell metabolism. 2017 May;25:1160-1175e11. [Full Text Article] [PubMed:28467932] [PMC:PMC5501713] Related Antibodies: LS-C143534.
4
Insulin expression and C-peptide in type 1 diabetes subjects implanted with stem cell-derived pancreatic endoderm cells in an encapsulation device. A M James Shapiro, David Thompson, Thomas W Donner, Melena D Bellin, Willa Hsueh, Jeremy Pettus, Jon Wilensky, Mark Daniels, Richard M Wang, Eugene P Brandon, Manasi S Jaiman, Evert J Kroon, Kevin A D'Amour, Howard L Foyt. Cell reports. Medicine. 2021 December;2:100466. [Full Text Article] [PubMed:35028608] [PMC:PMC8714853] Related Antibodies: LS-C124275.
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NKX6-1 (3)
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293T Cells
Myc-DDK (Flag)
37.7 kDa
20 µg/$150
NKX6-1 Protein - Recombinant NK6 Homeobox Protein 1 By SDS-PAGE
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97.8 kDa
10 µg/$284; 50 µg/$460; 100 µg/$735; 200 µg/$917; 1 mg/$2,037; 500 µg/$1,571; 5 mg/$3,207; 2 mg/$2,225
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37.7 kDa
100 µg/$494
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).