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NKX6-1

NK6 homeobox 1

Transcription factor which binds to specific A/T-rich DNA sequences in the promoter regions of a number of genes. Involved in transcriptional regulation in islet beta cells. Binds to the insulin promoter and is involved in regulation of the insulin gene. Together with NKX2-2 and IRX3 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class II proteins of neuronal progenitor factors, which are induced by SHH signals.

Gene Name: NK6 homeobox 1
Synonyms: NKX6-1, NKX6A, NK homeobox, family 6, A, NK6 homeobox 1, Homeobox protein Nkx-6.1, NKX6.1
Target Sequences: NM_006168 NP_006159.2 P78426

Publications (4)

1
Decreased GLUT2 and glucose uptake contribute to insulin secretion defects in MODY3/HNF1A hiPSC-derived mutant ß cells. Blaise Su Jun Low, Chang Siang Lim , Shirley Suet Lee Ding , Yaw Sing Tan , Natasha Hui Jin Ng, Vidhya Gomathi Krishnan, Su Fen Ang, Claire Wen Ying Neo, Chandra S Verma, Shawn Hoon, Su Chi Lim, E Shyong Tai, Adrian Kee Keong Teo. Nature communications. 2021 May;12:3133. [Full Text Article] [PubMed:34035238] [PMC:PMC8149827] Related Antibodies: LS-C124275.
2
Differentiation of human pluripotent stem cells into two distinct NKX6.1 populations of pancreatic progenitors. Idil I Aigha, Bushra Memon, Ahmed K Elsayed, Essam M Abdelalim. Stem cell research & therapy. 2018 Apr;9:83. [Full Text Article] [PubMed:29615106] [PMC:PMC5883581] Related Antibodies: LS-C124275.
3
Pseudotemporal Ordering of Single Cells Reveals Metabolic Control of Postnatal ß Cell Proliferation. Chun Zeng, Francesca Mulas, Yinghui Sui, Tiffany Guan, Nathanael Miller, Yuliang Tan, Fenfen Liu, Wen Jin, Andrea C Carrano, Mark O Huising, Orian S Shirihai, Gene W Yeo, Maike Sander. Cell metabolism. 2017 May;25:1160-1175e11. [Full Text Article] [PubMed:28467932] [PMC:PMC5501713] Related Antibodies: LS-C143534.
4
Insulin expression and C-peptide in type 1 diabetes subjects implanted with stem cell-derived pancreatic endoderm cells in an encapsulation device. A M James Shapiro, David Thompson, Thomas W Donner, Melena D Bellin, Willa Hsueh, Jeremy Pettus, Jon Wilensky, Mark Daniels, Richard M Wang, Eugene P Brandon, Manasi S Jaiman, Evert J Kroon, Kevin A D'Amour, Howard L Foyt. Cell reports. Medicine. 2021 December;2:100466. [Full Text Article] [PubMed:35028608] [PMC:PMC8714853] Related Antibodies: LS-C124275.
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☰ Filters
Antibodies (44)
Proteins (3)
ELISA Kits (1)
Over-Expression Lysate (2)
Primary (44)
Recombinant (1)
Sandwich (1)
NKX6-1 (48)
Human (43)
Mouse (22)
Rat (8)
Bovine (3)
Chimpanzee (3)
Dog (6)
Hamster (3)
Horse (6)
Monkey (3)
Pig (6)
Rabbit (6)
IHC (6)
IHC-P (8)
WB (39)
ELISA (16)
ICC (2)
IF (2)
Peptide-ELISA (1)
rabbit (41)
mouse (2)
goat (1)
Product Group
IHCPlus (1)
PathPlus Cancer (1)
IgG (17)
IgG2a,k (1)
IgG2b (1)
monoclonal mc (2)
polyclonal pc (42)
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96-Well Strip Plate (1)
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APC Conjugated (3)
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Cy3 Conjugated (1)
Cy7 Conjugated (1)
DY488 Conjugated (1)
DY550 Conjugated (1)
DY650 Conjugated (1)
FITC Conjugated (5)
HRP Conjugated (5)
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Unconjugated (17)
N-Terminus (8)
aa1-367 (8)
aa284-312 (7)
aa285-314 (7)
aa50-200 (5)
aa1-120 (2)
180-260 aa, Internal (1)
No (46)
Yes (2)
Cell Lysates (1)
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His-GST (1)
Myc-DDK (Flag) (2)
Human (2)
293T Cells (1)
E. coli (1)
HEK 293 Cells (1)
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NKX6-1 Goat anti-Human Polyclonal (aa1-120) Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
100 µg/$973
NKX6-1 Antibody - Nkx6.1 Antibody - IHC staining of Nkx6.1 in mouse intestine.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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NKX6-1 Rabbit anti-Human Polyclonal (aa50-200) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
0.1 ml/$386
NKX6-1 Antibody - Nkx6.1 Antibody - IHC staining of Nkx6.1 in mouse intestine.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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NKX6-1 Rabbit anti-Human Polyclonal (aa50-200) (Biotin) Antibody
Mouse, Human
IHC, IHC-P, WB
Biotin Conjugated
0.1 ml/$416
NKX6-1 Antibody - Nkx6.1 Antibody - IHC staining of Nkx6.1 in mouse intestine.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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NKX6-1 Rabbit anti-Human Polyclonal (aa50-200) (DY550) Antibody
Mouse, Human
IHC, IHC-P, WB
DY550 Conjugated
0.1 ml/$416
NKX6-1 Antibody - Nkx6.1 Antibody - IHC staining of Nkx6.1 in mouse intestine.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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NKX6-1 Rabbit anti-Human Polyclonal (aa50-200) (DY650) Antibody
Mouse, Human
IHC, IHC-P, WB
DY650 Conjugated
0.1 ml/$416
NKX6-1 Antibody - Nkx6.1 Antibody - IHC staining of Nkx6.1 in mouse intestine.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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NKX6-1 Rabbit anti-Human Polyclonal (aa50-200) (DY488) Antibody
Mouse, Human
IHC, IHC-P, WB
DY488 Conjugated
0.1 ml/$416
NKX6-1 Antibody - NKX6-1 antibody Western blot of Fetal Small Intestine lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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NKX6-1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Human
WB
Unconjugated
100 µl/$424
NKX6-1 Antibody - Western blot of NKX6-1 antibody.
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NKX6-1 Rabbit anti-Human Polyclonal (aa1-367) (FITC) Antibody
Human
WB
FITC Conjugated
100 µl/$348; 200 µl/$407; 500 µl/$605; 1 ml/$755; 2 ml/$993; 5 ml/$1,716
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NKX6-1 Mouse anti-Human Monoclonal (aa1-120) Antibody
Human
ELISA, ICC
Unconjugated
100 µg/$919
NKX6-1 Antibody - Human Pancreas: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Cancer
Fast Shipping
NKX6-1 Rabbit anti-Human Polyclonal Antibody
IHC-P
Unconjugated
50 µg/$460
NKX6-1 Antibody - Human Pancreas, Islets of Langerhans: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Fast Shipping
NKX6-1 Rabbit anti-Human Polyclonal Antibody
IHC-P
Unconjugated
50 µg/$460
NKX6-1 Antibody - Immunofluorescence staining of NKX6-1 in U251MG cells. Cells were fixed with 4% PFA, permeabilzed with 0.1% Triton X-100 in PBS, blocked with 10% serum, and incubated with rabbit anti-Human NKX6-1 polyclonal antibody (dilution ratio 1:200) at 4°C overnight. Then cells were stained with the Alexa Fluor 488-conjugated Goat Anti-rabbit IgG secondary antibody (green). Positive staining was localized to Nucleus.
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NKX6-1 Rabbit anti-Human Polyclonal Antibody
Human
ICC, IF
Unconjugated
100 µl/$412
NKX6-1 Antibody - Staining COLO cells by IF/ICC. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 min at 25°C. The primary antibody was diluted at 1:200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody.
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NKX6-1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
NKX6-1 Antibody - NKX6-1 monoclonal antibody (M01), clone 1B7 Western Blot analysis of NKX6-1 expression in HL-60.
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NKX6-1 Mouse anti-Human Monoclonal (1B7) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$423
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NKX6-1 Rabbit anti-Human Polyclonal (180-260 aa, Internal) Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
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NKX6-1 Rabbit anti-Human Polyclonal (aa284-312) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
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NKX6-1 Rabbit anti-Human Polyclonal (aa284-312) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
Select
NKX6-1 Rabbit anti-Human Polyclonal (aa284-312) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$952
Select
NKX6-1 Rabbit anti-Human Polyclonal (aa284-312) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
Select
NKX6-1 Rabbit anti-Human Polyclonal (aa284-312) (PE) Antibody
Human
ELISA, WB
PE Conjugated
200 µl/$952
Select
NKX6-1 Rabbit anti-Human Polyclonal (aa285-314) Antibody
Mouse, Human
ELISA, WB
Unconjugated
200 µl/$734
Select
NKX6-1 Rabbit anti-Human Polyclonal (aa285-314) (Biotin) Antibody
Mouse, Human
ELISA, WB
Biotin Conjugated
200 µl/$952
Select
NKX6-1 Rabbit anti-Human Polyclonal (aa285-314) (FITC) Antibody
Mouse, Human
ELISA, WB
FITC Conjugated
200 µl/$952
Select
NKX6-1 Rabbit anti-Human Polyclonal (aa285-314) (APC) Antibody
Mouse, Human
ELISA, WB
APC Conjugated
200 µl/$952
Select
NKX6-1 Rabbit anti-Human Polyclonal (aa285-314) (PE) Antibody
Mouse, Human
ELISA, WB
PE Conjugated
200 µl/$952
Viewing 1-25 of 48 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).