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NKX3-1

NK3 homeobox 1

Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells.

Gene Name: NK3 homeobox 1
Synonyms: NKX3-1, BAPX2, NK homeobox, family 3, A, NK3 homeobox 1, NKX3, NKX3.1, Homeobox protein Nkx-3.1, NKX3A
Target Sequences: NM_006167 NP_006158.2 Q99801

Publications (4)

1
Cooperativity of Nkx3.1 and Pten loss of function in a mouse model of prostate carcinogenesis. Kim MJ, Cardiff RD, Desai N, Banach-Petrosky WA, Parsons R, Shen MM, Abate-Shen C. Proceedings of the National Academy of Sciences of the United States of America. 2002 99:2884-9. [PubMed:11854455] [PMC:PMC122442]
2
A critical role for p27kip1 gene dosage in a mouse model of prostate carcinogenesis. Gao H, Ouyang X, Banach-Petrosky W, Borowsky AD, Lin Y, Kim M, Lee H, Shih WJ, Cardiff RD, Shen MM, Abate-Shen C. Proceedings of the National Academy of Sciences of the United States of America. 2004 101:17204-9. [PubMed:15569926] [PMC:PMC535400]
3
Nkx3.1 functions as para-transcription factor to regulate gene expression and cell proliferation in non-cell autonomous manner. Zhou J, Qin L, Tien JC, Gao L, Chen X, Wang F, Hsieh JT, Xu J. The Journal of biological chemistry. 2012 287:17248-56. (WB; Human, Rat) [PubMed:22465996] [PMC:PMC3366845]
4
NKX3.1 haploinsufficiency is prognostic for prostate cancer relapse following surgery or image-guided radiotherapy. Locke JA, Zafarana G, Ishkanian AS, Milosevic M, Thoms J, Have CL, Malloff CA, Lam WL, Squire JA, Pintilie M, Sykes J, Ramnarine VR, Meng A, Ahmed O, Jurisica I, van der Kwast T, Bristow RG. Clinical cancer research : an official journal of the American Association for Cancer Research. 2014 Jan;18:308-16. [Full Text Article] [PubMed:22048240] Related Antibodies: LS-B3435.
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Proteins (5)
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NKX3-1 (5)
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HEK 293 Cells
Myc-DDK (Flag)
26.2 kDa
20 µg/$1,107
NKX3-1 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
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293T Cells
Myc-DDK (Flag)
26.2 kDa
20 µg/$150
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Myc-DDK (Flag)
26.2 kDa
100 µg/$494
NKX3-1 Protein
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His
100 µg/$361; 500 µg/$739; 20 µg/$261
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).