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NKX2-1 / Thyroid-Specific TF

NK2 homeobox 1

TTF-1 / Thyroid-Specific TF is a protein initially identified as a thyroid-specific transcription factor. The encoded protein binds to the thyroglobulin promoter and regulates the expression of thyroid-specific genes but has also been shown to regulate the expression of genes involved in morphogenesis. Mutations and deletions in this gene are associated with benign hereditary chorea, choreoathetosis, congenital hypothyroidism, and neonatal respiratory distress, and may be associated with thyroid cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares the symbol/alias 'TTF1' with another gene, transcription termination factor 1, which plays a role in ribosomal gene transcription.

Gene Name: NK2 homeobox 1
Synonyms: NKX2-1, BCH, Benign chorea, Homeobox protein Nkx-2.1, NK-2, NKX2.1, NK-2 homolog A, Thyroid transcription factor 1, NK2 homeobox 1, TTF-1, BHC, Thyroid nuclear factor 1, TITF1, NKX2A, TEBP
Target Sequences: NM_003317 NP_003308.1 P43699

Publications (2)

1
Dorsal radial glial cells have the potential to generate cortical interneurons in human but not in mouse brain. Yu X, Zecevic N. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2011 31:2413-20. (IHC) [PubMed:21325508] [PMC:PMC3079257]
2
Generation of Complete Multi-Cell Type Lung Organoids From Human Embryonic and Patient-Specific Induced Pluripotent Stem Cells for Infectious Disease Modeling and Therapeutics Validation. Sandra L Leibel, Rachael N McVicar, Alicia M Winquist, Walter D Niles, Evan Y Snyder. Current protocols in stem cell biology. 2020 September;54:e118. [Full Text Article] [PubMed:32640120] [PMC:PMC7361156] Related Antibodies: LS-C264437.

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Proteins (7)
Over-Expression Lysate (4)
Recombinant (3)
NKX2-1 / Thyroid-Specific TF (7)
No (7)
GST (1)
GST, N-terminus (1)
His-GST (1)
Myc-DDK (Flag) (4)
Human (5)
293T Cells (2)
E. coli (1)
HEK 293 Cells (2)
Wheat Germ Extract (2)
Purified (1)
NKX2-1 / Thyroid-Specific TF Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
NKX2-1 / Thyroid-Specific TF Protein - 12.5% SDS-PAGE of human TITF1 stained with Coomassie Blue
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Wheat Germ Extract
GST
65 kDa
2 µg/$439
NKX2-1 / Thyroid-Specific TF Protein - Recombinant Transcription Termination Factor, RNA polymerase I By SDS-PAGE
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E. coli
His-GST
53.7 kDa
10 µg/$280; 50 µg/$437; 100 µg/$700; 200 µg/$872; 1 mg/$1,978; 500 µg/$1,519; 5 mg/$3,053; 2 mg/$2,164
NKX2-1 / Thyroid-Specific TF Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
38.4 kDa
100 µg/$494
NKX2-1 / Thyroid-Specific TF Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
38.4 kDa
20 µg/$150
NKX2-1 / Thyroid-Specific TF Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
38.6 kDa
20 µg/$150
NKX2-1 / Thyroid-Specific TF Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
38.6 kDa
100 µg/$494
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).