NISCH

nischarin

Acts either as the functional imidazoline-1 receptor (I1R) candidate or as a membrane-associated mediator of the I1R signaling. Binds numerous imidazoline ligands that induces initiation of cell-signaling cascades triggering to cell survival, growth and migration. Its activation by the agonist rilmenidine induces an increase in phosphorylation of mitogen-activated protein kinases MAPK1 and MAPK3 in rostral ventrolateral medulla (RVLM) neurons that exhibited rilmenidine-evoked hypotension By similarity. Blocking its activation with efaroxan abolished rilmenidine-induced mitogen-activated protein kinase phosphorylation in RVLM neurons By similarity. Acts as a modulator of Rac-regulated signal transduction pathways By similarity. Suppresses Rac1-stimulated cell migration by interacting with PAK1 and inhibiting its kinase activity By similarity. Also blocks Pak-independent Rac signaling by interacting with RAC1 and inhibiting Rac1-stimulated NF-kB response element and cyclin D1 promoter activation By similarity. Inhibits also LIMK1 kinase activity by reducing LIMK1 'Tyr-508' phosphorylation By similarity. Inhibits Rac-induced cell migration and invasion in breast and colon epithelial cells By similarity. Inhibits lamellipodia formation, when overexpressed By similarity. Plays a role in protection against apoptosis. Involved in association with IRS4 in the enhancement of insulin activation of MAPK1 and MAPK3. When overexpressed, induces a redistribution of cell surface ITGA5 integrin to intracellular endosomal structures.

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Products

Proteins (6)

Type

Over-Expression Lysate (2)

Recombinant (4)

Target

NISCH (6)

Publications

No (6)

Tag

GST, N-terminus (1)

His-GST (2)

Myc-DDK (Flag) (3)

Species

Human (4)

Mouse (1)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (2)

Wheat Germ Extract (1)

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NISCH Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G114799

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

166.5 kDa

Price:

100 µg/$494

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Human NISCH Protein (Recombinant GST, N-terminus) (aa1246-1345) - LS-G61777

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human NISCH Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G68685

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

166.5 kDa

Price:

20 µg/$1,107

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Human NISCH Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G82790

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

166.5 kDa

Price:

20 µg/$150

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Mouse NISCH Protein (Recombinant His-GST) (aa1335-1435) - LS-G11860

Source:

E. coli

Tag:

His-GST

Molecular Weight:

43.7 kDa

Price:

10 µg/$288; 50 µg/$487; 100 µg/$780; 200 µg/$972; 1 mg/$2,109; 500 µg/$1,636; 5 mg/$3,403; 2 mg/$2,298

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Human NISCH Protein (Recombinant His-GST) (aa1246-1346) - LS-G11861

Source:

E. coli

Tag:

His-GST

Molecular Weight:

43.8 kDa

Price:

10 µg/$262; 50 µg/$339; 100 µg/$512; 200 µg/$642; 1 mg/$1,623; 500 µg/$1,214; 5 mg/$2,562; 2 mg/$1,796

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