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NIRF / UHRF2
ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase
E3 ubiquitin-protein ligase that is an intermolecular hub protein in the cell cycle network. Through cooperative DNA and histone binding, may contribute to a tighter epigenetic control of gene expression in differentiated cells. Ubiquitinates cyclins, CCND1 and CCNE1, in an apparently phosphorylation-independent manner and induces G1 arrest. Also ubiquitinates PCNP leading to its degradation by the proteasome. E3 SUMO-, but not ubiquitin-, protein ligase for ZNF131.
| Gene Name: | ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase |
| Synonyms: | UHRF2, Np95-like RING finger protein, NIRF, Nuclear protein 97, URF2, RING finger protein 107, RNF107, RP11-472F14.2 |
| Target Sequences: | NM_152896 NP_690856.1 Q96PU4 |
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