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NIP3 / BNIP3

BCL2/adenovirus E1B 19kDa interacting protein 3

Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway.

Gene Name: BCL2/adenovirus E1B 19kDa interacting protein 3
Synonyms: BNIP3, NIP3
Target Sequences: NM_004052 NP_004043.3 Q12983

Publications (1)

1
Chronic autophagy is a cellular adaptation to tumor acidic pH microenvironments. Wojtkowiak JW, Rothberg JM, Kumar V, Schramm KJ, Haller E, Proemsey JB, Lloyd MC, Sloane BF, Gillies RJ. Cancer research. 2012 72:3938-47. [PubMed:22719070] Related Antibodies: LS-C98865.

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ELISA Kits (7)
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NIP3 / BNIP3 (7)
Human (2)
Mouse (2)
Rat (2)
Bovine (1)
96-Well Strip Plate (7)
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Cell Lysates (2)
Plasma (3)
Serum (3)
Tissue Homogenates (4)
NIP3 / BNIP3 ELISA Kit
Select
Custom
96-Well Strip Plate
Human
Colorimetric - 450nm (TMB)
1 Plate/$783
NIP3 / BNIP3 ELISA Kit
Select
Custom
96-Well Strip Plate
Bovine
Colorimetric - 450nm (TMB)
1 Plate/$783
NIP3 / BNIP3 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
NIP3 / BNIP3 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
NIP3 / BNIP3 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.469 - 30 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
NIP3 / BNIP3 ELISA Kit
Select
Sandwich CLIA
96-Well Strip Plate
Rat
0.055 - 40 ng/ml
Chemiluminescent
Cell Lysates, Tissue Homogenates
1 Plate/$1,034
NIP3 / BNIP3 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$893
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).