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NGF

nerve growth factor (beta polypeptide)

This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis.

Gene Name: nerve growth factor (beta polypeptide)
Family/Subfamily: NGF Beta , not assigned-NGF Beta
Synonyms: NGF, Beta-nerve growth factor, ProNGF, Beta-NGF, HSAN5, NGFB
Target Sequences: NM_002506 NP_002497.2 P01138

Publications (2)

1
Isorhynchophylline exerts antidepressant-like effects in mice via modulating neuroinflammation and neurotrophins: involvement of the PI3K/Akt/GSK-3ß signaling pathway. Xian YF, Ip SP, Li HQ, Qu C, Su ZR, Chen JN, Lin ZX. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2019 September;33:10393-10408. [Full Text Article] [PubMed:31233346]
2
Shp2-mediated MAPK pathway regulates ?Np63 in epithelium to promote corneal innervation and homeostasis. Yuka Okada, Yujin Zhang, Lingling Zhang, Lung-Kun Yeh, Yen-Chiao Wang, Shizuya Saika, Chia-Yang Liu. Laboratory investigation; a journal of technical methods and pathology. 2020 Apr;100:630-642. [Full Text Article] [PubMed:31653968] [PMC:PMC7102931] Related Antibodies: LS-C171793.

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Antibodies (105)
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NGF (105)
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NGF Antibody - Western blot testing of NGF antibody and rat brain tissue lysate
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NGF Rabbit anti-Human Polyclonal (aa162-173) Antibody
Xenopus, Bat, Mouse, Goat, Dog, Sheep, Bovine, Rat, Hamster, Pig, Horse, Human
WB
Unconjugated
100 µg/$575
NGF Antibody -  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
NGF Rabbit anti-Human Polyclonal (N-Terminus) (Magnetic beads) Antibody
Mouse, Rat, Human
IP
Magnetic beads Conjugated
100 µg/$399
NGF Antibody -  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
NGF Rabbit anti-Human Polyclonal (N-Terminus) (Sepharose) Antibody
Mouse, Rat, Human
IP
Sepharose Conjugated
100 µg/$399
NGF Antibody - Anti-Human ß-NGF Western Blot Unreduced
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NGF Mouse anti-Human Monoclonal Antibody
Human
ELISA, WB
Unconjugated
500 µg/$326
NGF Antibody - Western Blot (non-reducing) of NGF antibody. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
NGF Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
50 µg/$356; 100 µg/$396
NGF Antibody - Western Blot (non-reducing) of NGF antibody. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
NGF Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
25 µg/$356; 50 µg/$396
Select
NGF Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
500 µg/$393
NGF Antibody - Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Neuroscience
NGF Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
NGF Antibody - Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Neuroscience
NGF Rabbit anti-Human Polyclonal (Leu82) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
NGF Antibody - Cell Proliferation Induced by beta-NGF was Neutralized by Human beta-NGF Antibody. Recombinant Human beta-NGF (Catalog #11050-HNAC) stimulates proliferation of TF-1 human erythroleukemic cells. Proliferation elicited by 5 ng/mL of Recombinant Human beta-NGF is neutralized by increasing concentrations of Rabbit Anti-Human beta-NGF neutralizing Monoclonal Antibody (Catalog # 11050-RC6). The IC50 is typically 17-70 ng/mL.
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NGF Rabbit anti-Human Monoclonal (Preservative Free) (RC6) Antibody
Human
Block, ELISA, Neut
Unconjugated, Preservative Free
200 µg/$361; 500 µg/$436
NGF Antibody - Formalin-fixed and paraffin-embedded human brain tissue reacted with NGFB antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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NGF Rabbit anti-Human Polyclonal (aa84-115) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
Select
NGF Rabbit anti-Human Monoclonal (Preservative Free) (422) Antibody
Human
ELISA
Unconjugated, Preservative Free
20 µl/$286; 100 µl/$435
Select
NGF Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA
HRP Conjugated
50 µg/$294; 100 µg/$360
Select
NGF Mouse anti-Bovine Monoclonal (Biotin) Antibody
Mouse, Bovine, Human, Reptile
ELISA
Biotin Conjugated
200 µg/$442
Select
NGF Rabbit anti-Mouse Polyclonal Antibody
Chicken, Mouse, Rat, Human
ELISA, Func, IHC, WB
Unconjugated
20 µg/$907
Select
NGF Rabbit anti-Mouse Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
500 µg/$649
NGF Antibody - WB of NGF antibody.
Select
NGF Rabbit anti-Human Polyclonal (aa122-241) Antibody
Human
ELISA, WB
Unconjugated
10 µg/$318; 100 µg/$470
NGF Antibody - Cell Proliferation Induced by beta-NGF was Neutralized by Human beta-NGF Antibody. Recombinant Human beta-NGF (Catalog 11050-HNAC) stimulates proliferation in the TF-1 human erythroleukemic cell line. Proliferation elicited by Recombinant Human beta-NGF (10 ng/mL) is neutralized by increasing concentrations of Rabbit Anti-Human beta-NGF Monoclonal Antibody (Catalog 11050-R711). The IC50 is typically 0.048-0.19 ug/mL.
Select
NGF Rabbit anti-Human Monoclonal (Preservative Free) (R711) Antibody
Human
Block, ELISA, Neut
Unconjugated, Preservative Free
200 µg/$361; 500 µg/$436
Select
NGF Rabbit anti-Mouse Monoclonal (Preservative Free) (016) Antibody
Mouse
ELISA
Unconjugated, Preservative Free
100 µl/$412
Select
NGF Mouse anti-Bovine Monoclonal Antibody
Bovine
WB
Unconjugated
100 µg/$842
Select
NGF Rabbit anti-Human Monoclonal (Preservative Free) (B64) Antibody
Human
ELISA
Unconjugated, Preservative Free
20 µl/$286; 100 µl/$435
Select
NGF Rabbit anti-Human Monoclonal (Preservative Free) (HRP) (422) Antibody
Human
ELISA
HRP Conjugated, Preservative Free
20 µl/$308; 100 µg/$511
NGF Antibody - Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Neuroscience
NGF Rabbit anti-Human Polyclonal (aa33-82) Antibody
Mouse, Rat, Human
IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
Select
NGF Rabbit anti-Mouse Polyclonal Antibody
Chicken, Mouse, Rat, Human
ELISA, Func, IHC, WB
Unconjugated
250 µl/$826
Select
NGF Sheep anti-Mouse Polyclonal Antibody
Chicken, Mouse, Rat, Human
ELISA, Func, IHC, WB
Unconjugated
250 µl/$786
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).