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NFYA
nuclear transcription factor Y, alpha
NFYA is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds to CCAAT motifs in the promoter regions in a variety of genes. Subunit A associates with a tight dimer composed of the B and C subunits, resulting in a trimer that binds to DNA with high specificity and affinity. The sequence specific interactions of the complex are made by the A subunit, suggesting a role as the regulatory subunit. In addition, there is evidence of post-transcriptional regulation in this gene product, either by protein degradation or control of translation. Further regulation is represented by alternative splicing in the glutamine-rich activation domain, with clear tissue-specific preferences for the two isoforms.
| Gene Name: | nuclear transcription factor Y, alpha |
| Synonyms: | NFYA, CBF-A, CBF-B, HAP2, HAP2 CCAAT-binding protein, NF-YA |
| Target Sequences: | NM_021705 NP_068351.1 P23511 |
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