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NFYA
nuclear transcription factor Y, alpha
NFYA is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds to CCAAT motifs in the promoter regions in a variety of genes. Subunit A associates with a tight dimer composed of the B and C subunits, resulting in a trimer that binds to DNA with high specificity and affinity. The sequence specific interactions of the complex are made by the A subunit, suggesting a role as the regulatory subunit. In addition, there is evidence of post-transcriptional regulation in this gene product, either by protein degradation or control of translation. Further regulation is represented by alternative splicing in the glutamine-rich activation domain, with clear tissue-specific preferences for the two isoforms.
| Gene Name: | nuclear transcription factor Y, alpha |
| Synonyms: | NFYA, CBF-A, CBF-B, HAP2, HAP2 CCAAT-binding protein, NF-YA |
| Target Sequences: | NM_021705 NP_068351.1 P23511 |
![NFYA Antibody - Anti-NF-Y(A subunit) Antibody - Western Blot. CHO-7 cells were cultured in the absence (I) or presence (S) of cholesterol. Equivalent aliquots of chromatin from each sample containing ~50 ug of total protein were subjected to analysis by SDS-PAGE and western blot. After transfer, the membrane was probed using anti-NF-YA as the primary antibody at a 1:1000 dilution, followed by reaction with HRP conjugated Goat-anti-Rabbit IgG [H&L]. Signal was developed using an ECL kit followed by autoradiography using a 30 exposure. The antibody recognizes NF-YA as a doublet of ~42 kD in size.](https://lsbio-7d62.kxcdn.com/image2/nfya-antibody-n-terminus-ls-c18769/62663_185419.jpg)
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