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Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.
Gene Name: | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta |
Synonyms: | NFKBIB, IKBB, I-kappa-B-beta, IkappaBbeta, NF-kappa-B inhibitor beta, IkB-beta, TRIP9, TRIP-9, IkB-B, NF-kappa-BIB, TR-interacting protein 9 |
Target Sequences: | NM_002503 NP_002494.2 Q15653 |
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