NFKB1 / NF-Kappa-B

nuclear factor of kappa light polypeptide gene enhancer in B-cells 1

NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and RelB-p50 complexes are transcriptional activators. The NF-kappa-B p50-p50 homodimer is a transcriptional repressor, but can act as a transcriptional activator when associated with BCL3. NFKB1 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p105 and generation of p50 by a cotranslational processing. The proteasome-mediated process ensures the production of both p50 and p105 and preserves their independent function, although processing of NFKB1/p105 also appears to occur post-translationally. p50 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. In a complex with MAP3K8, NFKB1/p105 represses MAP3K8-induced MAPK signaling; active MAP3K8 is released by proteasome-dependent degradation of NFKB1/p105.

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Proteins (12)

Type

Over-Expression Lysate (2)

Recombinant (10)

Target

NFKB1 / NF-Kappa-B (12)

Publications

No (12)

Tag

6His, N-terminus (1)

GST (1)

GST, N-terminus (1)

His (2)

His, N-Terminal (1)

His-GST (2)

His-T7 (1)

Myc-DDK (Flag) (3)

Species

Chicken (1)

Human (8)

Mouse (1)

Rat (1)

Source

293T Cells (1)

E. coli (6)

HEK 293 Cells (2)

Sf21 Cells (1)

Wheat Germ Extract (2)

Purification

Purified (2)

Low Endotoxin Level

Low endotoxin level (1)

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Human NFKB1 / NF-Kappa-B Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66452

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

105.2 kDa

Price:

20 µg/$1,107

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Human NFKB1 / NF-Kappa-B Protein (Recombinant GST, N-terminus) (aa860-969) - LS-G59396

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human NFKB1 / NF-Kappa-B Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G77744

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

105.2 kDa

Price:

20 µg/$150

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Mouse NFKB1 / NF-Kappa-B Protein (Recombinant His-T7) (aa40-365) - LS-G14358

Source:

E. coli

Tag:

His-T7

Molecular Weight:

40.6 kDa

Price:

10 µg/$271; 50 µg/$382; 100 µg/$610; 200 µg/$762; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998

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Human NFKB1 / NF-Kappa-B Protein (Recombinant His, N-Terminal) (Pro42-Met367) - LS-G14359

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

40.6 kDa

Price:

10 µg/$267; 50 µg/$352; 100 µg/$562; 200 µg/$702; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900

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Human NFKB1 / NF-Kappa-B Protein (Recombinant His-GST) (aa805-892) - LS-G14369

Source:

E. coli

Tag:

His-GST

Molecular Weight:

42.1 kDa

Price:

10 µg/$267; 50 µg/$352; 100 µg/$562; 200 µg/$702; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900

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Chicken NFKB1 / NF-Kappa-B Protein (Recombinant His) (aa47-372) - LS-G24515

Source:

E. coli

Tag:

His

Molecular Weight:

40.6 kDa

Price:

10 µg/$290; 50 µg/$500; 100 µg/$797; 200 µg/$997; 1 mg/$2,139; 500 µg/$1,662; 5 mg/$3,487; 2 mg/$2,329

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Rat NFKB1 / NF-Kappa-B Protein (Recombinant His-GST) (aa352-439) - LS-G24516

Source:

E. coli

Tag:

His-GST

Molecular Weight:

39.4 kDa

Price:

10 µg/$282; 50 µg/$450; 100 µg/$717; 200 µg/$897; 1 mg/$2,010; 500 µg/$1,547; 5 mg/$3,137; 2 mg/$2,198

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Human NFKB1 / NF-Kappa-B Protein (Recombinant GST) (Full Length) - LS-G29506

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

131.8 kDa

Price:

10 µg/$479; 25 µg/$670

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Human NFKB1 / NF-Kappa-B Protein (Recombinant 6His, N-terminus) - LS-G146093

Source:

E. coli

Tag:

6His, N-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

49.7 kDa

Price:

10 µg/$329; 50 µg/$580

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Human NFKB1 / NF-Kappa-B Protein (Recombinant His) - LS-G4012

Source:

Sf21 Cells

Tag:

His

Price:

2 µg/$428

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NFKB1 / NF-Kappa-B Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G116921

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

105.2 kDa

Price:

100 µg/$494

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