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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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We could not find product '(ID:368554)'. Here are some alternate products to this target that might be of interest to you.



NFKB1 / NF-Kappa-B

nuclear factor of kappa light polypeptide gene enhancer in B-cells 1

NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and RelB-p50 complexes are transcriptional activators. The NF-kappa-B p50-p50 homodimer is a transcriptional repressor, but can act as a transcriptional activator when associated with BCL3. NFKB1 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p105 and generation of p50 by a cotranslational processing. The proteasome-mediated process ensures the production of both p50 and p105 and preserves their independent function, although processing of NFKB1/p105 also appears to occur post-translationally. p50 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. In a complex with MAP3K8, NFKB1/p105 represses MAP3K8-induced MAPK signaling; active MAP3K8 is released by proteasome-dependent degradation of NFKB1/p105.

Gene Name: nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
Family/Subfamily: Apoptosis , not assigned-Other
Synonyms: NFKB1, Ebp- 1, EBP-1, NF-KappaB p50, NFkappaB, NFKB-p50, KBF1, NF-kappa-B, NF-kappaB, NF-kB1, NFKB-p105, p105, p50, DNA binding factor KBF1, DNA-binding factor KBF1, NF-kappabeta
Target Sequences: NM_003998 NP_003989.2 P19838

Publications (6)

1
Transcriptional regulation of parathyroid hormone-related protein promoter P2 by NF-kappaB in adult T-cell leukemia/lymphoma. Nadella MV, Dirksen WP, Nadella KS, Shu S, Cheng AS, Morgenstern JA, Richard V, Fernandez SA, Huang TH, Guttridge D, Rosol TJ. Leukemia. 2007 21:1752-62. (WB) [PubMed:17554373] [PMC:PMC2676796]
2
Requirement for both JAK-mediated PI3K signaling and ACT1/TRAF6/TAK1-dependent NF-kappaB activation by IL-17A in enhancing cytokine expression in human airway epithelial cells. Huang F, Kao CY, Wachi S, Thai P, Ryu J, Wu R. Journal of immunology (Baltimore, Md. : 1950). 2007 179:6504-13. [PubMed:17982039] Related Antibodies: LS-B1668.
3
Requirements for two proximal NF-kappaB binding sites and IkappaB-zeta in IL-17A-induced human beta-defensin 2 expression by conducting airway epithelium. Kao CY, Kim C, Huang F, Wu R. The Journal of biological chemistry. 2008 283:15309-18. [PubMed:18362142] [PMC:PMC2397472] Related Antibodies: LS-B1668.
4
Nuclear factor-B contributes to neuron-dependent induction of glutamate transporter-1 expression in astrocytes. Ghosh M, Yang Y, Rothstein JD, Robinson MB. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2011 31:9159-69. [PubMed:21697367] [PMC:PMC3138498] Related Antibodies: LS-B716.
5
NF-B regulates MICA gene transcription in endothelial cell through a genetically inhibitable control site. Lin D, Lavender H, Soilleux EJ, O'Callaghan CA. The Journal of biological chemistry. 2012 287:4299-310. [PubMed:22170063] [PMC:PMC3281736] Related Antibodies: LS-B1668.
6
1,25-dihydroxyvitamin D3 impairs NF- kappa B activation in human naïve B cells. Geldmeyer-Hilt K, Heine G, Hartmann B, Baumgrass R, Radbruch A, Worm M. Biochemical and biophysical research communications. 2011 Apr;407:699-702. [Full Text Article] [PubMed:21420936] Related Antibodies: LS-B1668.
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Viewing 1-25 of 234 items
NFKB1 / NF-Kappa-B Antibody - Anti-NFKB1 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 15 ug/ml.
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(4) Publication(s)
Mouse Monoclonal [clone 4D1] (IgG1) to Human NFKB1 / NF-Kappa-B
Human
IF, IHC, IHC-P, WB
Unconjugated
50µg   0.5mg/ml   $425.00
NFKB1 / NF-Kappa-B Antibody - Anti-NF-KappaB p105 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 5-10 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Rabbit Polyclonal (IgG) to Human NFKB1 / NF-Kappa-B
Zebrafish, Pig, Horse, Bat, Mouse, Dog, Guinea pig, Bovine, Rat, Human, Monkey
IHC, IHC-P, WB
Unconjugated
100µl   $485.00
NFKB1 / NF-Kappa-B Antibody - Anti-NFKB1 antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:500.
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(1) Publication(s)
Rabbit Polyclonal to Human NFKB1 / NF-Kappa-B
Human
ELISA, GS, IF, IHC, IHC-P, IP, WB
Unconjugated
50µl   85mg/ml   $485.00
NFKB1 / NF-Kappa-B Antibody - Anti-NFKB1 antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.
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Rabbit Polyclonal (IgG) to Human NFKB1 / NF-Kappa-B
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50µl   $425.00
NFKB1 / NF-Kappa-B Antibody - Anti-NFKB1 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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Rat Monoclonal [clone NF5E6] (IgG1) to Human NFKB1 / NF-Kappa-B
Human
IHC, IHC-P, WB
Unconjugated
50µg   1mg/ml   $505.00
NFKB1 / NF-Kappa-B Antibody - Anti-NFKB1 antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:500.
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Rabbit Polyclonal to Human NFKB1 / NF-Kappa-B
Human
ELISA, IF, IHC, IHC-P, IP, WB
Unconjugated
50µl   90mg/ml   $485.00
NFKB1 / NF-Kappa-B Antibody - Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Rabbit Polyclonal (IgG) to Human NFKB1 / NF-Kappa-B
Human
ChrIP, ELISA, IHC, IHC-P, WB
Unconjugated
50µg   $425.00
NFKB1 / NF-Kappa-B Antibody - NFKB1 antibody Western blot of 1 Cell lysate. Antibody concentration 1 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Rabbit Polyclonal to Human NFKB1 / NF-Kappa-B
Rabbit, Mouse, Dog, Rat, Horse, Human, Monkey
WB
Unconjugated
100µl   0.5mg/ml   $365.00
NFKB1 / NF-Kappa-B Antibody - IHC of paraffin-embedded human intima cancer tissues (left) and human bladder cancer tissues (right) using NFKB1 mouse monoclonal antibody with DAB staining.
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Mouse Monoclonal [clone 5D10D11] (IgG2a) to Human NFKB1 / NF-Kappa-B
Human
ELISA, Flo, IF, IHC, WB
Unconjugated
100µl   $365.00
NFKB1 / NF-Kappa-B Antibody - Immunoperoxidase of monoclonal antibody to NFKB1 on formalin-fixed paraffin-embedded human salivary gland. [antibody concentration 3 ug/ml]
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Mouse Monoclonal [clone 3F6] (IgG1,k) to Human NFKB1 / NF-Kappa-B
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
100µg   $365.00
NFKB1 / NF-Kappa-B Antibody - Immunohistochemical analysis of NF-kappaB p105/p50 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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Rabbit Polyclonal to Human NFKB1 / NF-Kappa-B
Chicken, Mouse, Dog, Rat, Pig, Human
ICC, IF, IHC, IHC-P, IP, WB
Unconjugated
100µl   1mg/ml   $245.00
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Rabbit Monoclonal (IgG) to Human NFKB1 / NF-Kappa-B
Mouse, Rat, Human
ChrIP, Flo, IF, IHC, IP, WB
Unconjugated
50µl   $295.00
NFKB1 / NF-Kappa-B Antibody - Immunohistochemistry (IHC) analysis of paraffin-embedded human intima cancer tissues (left) and human bladder cancer tissues (right) with DAB staining using NFkappaB-p105/p50 Monoclonal Antibody.
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Mouse Monoclonal (IgG2a) to Human NFKB1 / NF-Kappa-B
Human
ELISA, Flo, IF, IHC, WB
Unconjugated
100µl   $345.00
NFKB1 / NF-Kappa-B Antibody - NFkB p50 Antibody in Immunofluorescence (IF)
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Mouse Monoclonal [clone 5D10D11] (IgG1) to Human NFKB1 / NF-Kappa-B
Human
ChIP-Seq, Flo, ICC, IF, IHC-P, WB
Unconjugated
100µg   $445.00
NFKB1 / NF-Kappa-B Antibody
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Rabbit Polyclonal (IgG) to Human NFKB1 / NF-Kappa-B
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
NFKB1 / NF-Kappa-B Antibody
Select
Rabbit Polyclonal (IgG) to Human NFKB1 / NF-Kappa-B
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
NFKB1 / NF-Kappa-B Antibody - Immunoperoxidase of monoclonal antibody to NFKB1 on formalin-fixed paraffin-embedded human colon. [antibody concentration 1.5 ug/ml]
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Mouse Monoclonal [clone 4A11] (IgG1,k) to Human NFKB1 / NF-Kappa-B
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
100µg   $365.00
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Mouse Monoclonal (IgG1) to Human NFKB1 / NF-Kappa-B
Human
ELISA, Flo, ICC, IHC, WB
Unconjugated
50µl   1mg/ml   $315.00; 100µl   1mg/ml   $375.00; 200µl   1mg/ml   $435.00
NFKB1 / NF-Kappa-B Antibody - Immunohistochemistry (IHC) analysis of paraffin-embedded prostate tissues (left) and bladder cancer tissues (right) with DAB staining using NFkappaB-p105/p50 Monoclonal Antibody.
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Mouse Monoclonal (IgG2a) to Human NFKB1 / NF-Kappa-B
Human
ELISA, Flo, IHC, WB
Unconjugated
100µl   $345.00
NFKB1 / NF-Kappa-B Antibody - Immunohistochemical analysis of NF-kappaB p105/p50 (pS337) staining in human prostate cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Select
Rabbit Polyclonal to Human NFKB1 / NF-Kappa-B
Chicken, Bovine, Mouse, Dog, Rat, Pig, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100µl   1mg/ml   $265.00
NFKB1 / NF-Kappa-B Antibody - Immunohistochemical analysis of NF-kappaB p105 staining in human prostate cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Select
Rabbit Polyclonal to Human NFKB1 / NF-Kappa-B
Mouse, Rat, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
30µl   1mg/ml   $205.00; 100µl   1mg/ml   $245.00; 200µl   1mg/ml   $305.00
NFKB1 / NF-Kappa-B Antibody - Immunohistochemistry of paraffin-embedded human tonsil using NFKB1 antibody at dilution of 1:100 (40x lens).
Select
Rabbit Polyclonal (IgG) to Human NFKB1 / NF-Kappa-B
Human
IF, IHC, IP, WB
Unconjugated
50µl   $235.00; 100µl   $295.00; 200µl   $385.00
NFKB1 / NF-Kappa-B Antibody
Select
Rabbit Polyclonal (IgG) to Human NFKB1 / NF-Kappa-B
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
NFKB1 / NF-Kappa-B Antibody - Immunohistochemical analysis of NF-kappaB p105 (pS927) staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Select
Rabbit Polyclonal to Human NFKB1 / NF-Kappa-B
Mouse, Rat, Human
ICC, IF, IHC, IHC-P, IP, WB
Unconjugated
100µl   1mg/ml   $265.00
NFKB1 / NF-Kappa-B Antibody - IHC of paraffin-embedded prostate tissues (left) and bladder cancer tissues (right) using NFKB1 mouse monoclonal antibody with DAB staining.
Select
Mouse Monoclonal [clone 5D10] (IgG2a) to Human NFKB1 / NF-Kappa-B
Human
ELISA, Flo, IHC, WB
Unconjugated
100µl   $365.00

Viewing 1-25 of 234 items


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For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).