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NFE2L2 / NRF2

nuclear factor, erythroid 2-like 2

Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.

Gene Name:	nuclear factor, erythroid 2-like 2
Synonyms:	NFE2L2, NF-E2-related factor 2, NFE2-related factor 2, NRF2
Target Sequences:	NM_006164 NP_006155.2 Q16236

Publications (6)

Neuroprotective effects of the triterpenoid, CDDO methyl amide, a potent inducer of Nrf2-mediated transcription. Yang L, Calingasan NY, Thomas B, Chaturvedi RK, Kiaei M, Wille EJ, Liby KT, Williams C, Royce D, Risingsong R, Musiek ES, Morrow JD, Sporn M, Beal MF. PloS one. 2009 4:e5757. (WB) [PubMed:19484125] [PMC:PMC2684590]

Up-regulation of human CYP2J2 in HepG2 cells by butylated hydroxyanisole is mediated by c-Jun and Nrf2. Lee AC, Murray M. Molecular pharmacology. 2010 77:987-94. (WB) [PubMed:20194533]

Adrenergic regulation during acute hepatic infection with Entamoeba histolytica in the hamster: involvement of oxidative stress, Nrf2 and NF-KappaB. Aldaba-Muruato LR, Muñoz-Ortega MH, Macías-Pérez JR, Pulido-Ortega J, Martínez-Hernández SL, Ventura-Juárez J. Parasite (Paris, France). 2017 24:46. (Human) [Full Text Article] [PubMed:29185982] [PMC:PMC5706999] Related Antibodies: LS-C154863.

DHA protects PC12 cells against oxidative stress and apoptotic signals through the activation of the NFE2L2/HO-1 axis. Maria Elisabetta Clementi, Giacomo Lazzarino, Beatrice Sampaolese, Anna Brancato, Giuseppe Tringali. International journal of molecular medicine. 2019 Jun;43:2523-2531. [Full Text Article] [PubMed:31017264]

Impairment of IGF-1 Signaling and Antioxidant Response Are Associated with Radiation Sensitivity and Mortality. Saeed Y Aghdam, Doreswamy Kenchegowda, Gregory P Holmes-Hampton, Maria Moroni, Sanchita P Ghosh. International journal of molecular sciences. 2021 Jan;22:451. [Full Text Article] [PubMed:33466349] [PMC:PMC7795011]

Intracerebral injection of oil cyst content of human craniopharyngioma (oil machinery fluid) as a toxic model in the rat brain. Tena-Suck ML, Hern[Character e1]ndez-Campos ME, Ortiz-Plata A, Salinas-Lara C, Col[Character ed]n-Gonz[Character e1]lez AL, Santamar[Character ed]a A. Acta histochemica. 2014 Apr;116:448-56. [Full Text Article] [PubMed:24192215] Related Antibodies: LS-C118534.

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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