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NFAT1 / NFATC2
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NFAT1 / NFATC2 is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants encoding different isoforms have been characterized.
| Gene Name: | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 |
| Synonyms: | NFATC2, NF-ATc2, NF-ATp, NFAT1, NFAT pre-existing subunit, NFATP |
| Target Sequences: | NM_012340 NP_036472.2 Q13469 |
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