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NF-L / NEFL
neurofilament, light polypeptide
Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y.
| Gene Name: | neurofilament, light polypeptide |
| Synonyms: | NEFL, 68 kDa neurofilament protein, CMT1F, CMT2E, NF68, NF-L, NFL, Neurofilament subunit NF-L, PPP1R110, Neurofilament light polypeptide, CMTDIG |
| Target Sequences: | NM_006158 NP_006149.2 P07196 |
Publications (5)
1
Neuron-glia interactions underlie ALS-like axonal cytoskeletal pathology. King AE, Dickson TC, Blizzard CA, Woodhouse A, Foster SS, Chung RS, Vickers JC. Neurobiology of aging. 2011 32:459-69. (ICC, IHC; Mouse)
[PubMed:19427060]
2
NYAP: a phosphoprotein family that links PI3K to WAVE1 signalling in neurons. Yokoyama K, Tezuka T, Kotani M, Nakazawa T, Hoshina N, Shimoda Y, Kakuta S, Sudo K, Watanabe K, Iwakura Y, Yamamoto T. The EMBO journal. 2011 30:4739-54.
[PubMed:21946561]
[PMC:PMC3243607]
3
Microbiome-Derived Lipopolysaccharide (LPS) Selectively Inhibits Neurofilament Light Chain (NF-L) Gene Expression in Human Neuronal-Glial (HNG) Cells in Primary Culture. Lukiw WJ, Cong L, Jaber V, Zhao Y. Frontiers in neuroscience. 2018 December;12:896. [Full Text Article]
[PubMed:30568571]
[PMC:PMC6289986]
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Antibodies
(65)
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(65)
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NF-L / NEFL
(65)
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(55)
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(31)
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(26)
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(7)
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(13)
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(27)
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(17)
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(55)
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(14)
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(32)
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(28)
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(3)
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(13)
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(14)
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(8)
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(28)
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(35)
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(4)
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(4)
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(3)
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(1)
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(41)
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(8)
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(3)
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(2)
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(1)
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(1)
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(1)
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(1)
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(1)
Publications
No
(65)
NF-L / NEFL Mouse anti-Human Monoclonal (DA2) Antibody
Human
ELISA, IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
200 µg/$890
NF-L / NEFL Mouse anti-Human Monoclonal (HRP) Antibody
Human
ELISA, IHC, IP, WB
HRP Conjugated
100 µl/$1,129
NF-L / NEFL Mouse anti-Human Monoclonal (Biotin) Antibody
Human
ELISA, IHC, IP, WB
Biotin Conjugated
100 µl/$1,129
NF-L / NEFL Mouse anti-Human Monoclonal (FITC) Antibody
Human
ELISA, IHC, IP, WB
FITC Conjugated
100 µl/$1,129
NF-L / NEFL Mouse anti-Human Monoclonal (APC) Antibody
Human
ELISA, IHC, IP, WB
APC Conjugated
100 µl/$1,129
NF-L / NEFL Mouse anti-Human Monoclonal (PE) Antibody
Human
ELISA, IHC, IP, WB
PE Conjugated
100 µl/$1,129
NF-L / NEFL Chicken anti-Human Polyclonal Antibody
Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
NF-L / NEFL Mouse anti-Pig Monoclonal (DA2) Antibody
Mouse, Bovine, Rat, Pig, Human
ICC, IF, WB
Unconjugated
100 µl/$376
Cancer
NF-L / NEFL Mouse anti-Human Monoclonal (2F11) Antibody
Opossum, Human
IHC, IHC-Fr, IHC-P, WB
Unconjugated
0.1 mg/$485
NF-L / NEFL Mouse anti-Human Monoclonal (2G10) Antibody
Human
ELISA, Flo, IF, IHC, WB
Unconjugated
100 µl/$459
NF-L / NEFL Mouse anti-Pig Monoclonal (DA2) Antibody
Avian, Pig, Mammal, Mouse, Rat, Human
IF, IHC, IHC-Fx, IHC-P, WB
Unconjugated
0.05 ml/$386
NF-L / NEFL Rabbit anti-Human Polyclonal (aa295-344) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA
Unconjugated
100 µl/$515
NF-L / NEFL Mouse anti-Human Monoclonal (7D1) Antibody
Mouse, Bovine, Rat, Pig, Human
ICC, IF, WB
Unconjugated
100 µl/$376
NF-L / NEFL Mouse anti-Human Monoclonal (1H3) Antibody
Human
Flo, ICC, IF, IHC, WB
Unconjugated
100 µg/$503
Cancer
NF-L / NEFL Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC-P, WB
Unconjugated
50 µg/$460
NF-L / NEFL Mouse anti-Human Monoclonal (1H3) Antibody
Human
ELISA, Flo, IF, IHC, WB
Unconjugated
100 µl/$459
NF-L / NEFL Rabbit anti-Human Polyclonal Antibody
Rat, Human
ICC, IF, IHC, WB
Unconjugated
100 µl/$376
NF-L / NEFL Rabbit anti-Human Polyclonal (aa128-271) Antibody
Human
ELISA, IF, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
NF-L / NEFL Rabbit anti-Human Polyclonal (aa128-271) (Biotin) Antibody
Human
ELISA
Biotin Conjugated
50 µg/$294; 100 µg/$360
NF-L / NEFL Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
NF-L / NEFL Rabbit anti-Human Polyclonal (aa281-396) (Biotin) Antibody
Mouse, Rat, Human
WB
Biotin Conjugated
100 µl/$319; 200 µl/$365; 500 µl/$519; 1 ml/$596
NF-L / NEFL Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Bovine, Rat, Pig, Human, Monkey
IHC-P, WB
Unconjugated
50 µl/$460
Cancer
NF-L / NEFL Rabbit anti-Human Recombinant Monoclonal (NEFL/2983R) Antibody
Human
IHC-P
Unconjugated
100 µg/$525
NF-L / NEFL Mouse anti-Human Monoclonal (aa1-360) (Carrier-free) (OTI3G2) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
NF-L / NEFL Mouse anti-Pig Monoclonal Antibody
Rat, Pig, Human
IHC, IHC-Fr, IHC-P, WB
Unconjugated
100 µg/$564
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product results
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