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Neuroserpin

serpin peptidase inhibitor, clade I (neuroserpin), member 1

Neuroserpin is a member of the serpin superfamily of serine proteinase inhibitors. The protein is primarily secreted by axons in the brain, and preferentially reacts with and inhibits tissue-type plasminogen activator. It is thought to play a role in the regulation of axonal growth and the development of synaptic plasticity. Mutations in this gene result in familial encephalopathy with neuroserpin inclusion bodies (FENIB), which is a dominantly inherited form of familial encephalopathy and epilepsy characterized by the accumulation of mutant neuroserpin polymers. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Gene Name: serpin peptidase inhibitor, clade I (neuroserpin), member 1
Synonyms: SERPINI1, Neuroserpin, Peptidase inhibitor 12, PI12, Serpin I1, PI-12, Protease inhibitor 12
Target Sequences: NM_005025 NP_005016.1 Q99574

Publications (1)

1
Stress-Induced Cellular Clearance Is Mediated by the SNARE Protein ykt6 and Disrupted by a-Synuclein. Leah K Cuddy, Willayat Y Wani, Martino L Morella, Caleb Pitcairn, Kotaro Tsutsumi, Kristina Fredriksen, Craig J Justman, Tom N Grammatopoulos, Nandkishore R Belur, Friederike Zunke, Aarthi Subramanian, Amira Affaneh, Peter T Lansbury Jr, Joseph R Mazzulli. Neuron. 2019 December;104:869-884.e11. [Full Text Article] [PubMed:31648898] [PMC:PMC6895429]

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Proteins (6)
Recombinant (6)
Neuroserpin (6)
No (6)
GST (1)
His (3)
Human (5)
Mouse (1)
E. coli (3)
Human Cells (2)
Wheat Germ Extract (1)
Purified (3)
Low endotoxin level (3)
Biologically active (2)
Neuroserpin Protein - Recombinant Neuroserpin By SDS-PAGE
Select
E. coli
His
48.4 kDa
10 µg/$273; 50 µg/$392; 100 µg/$625; 200 µg/$782; 1 mg/$1,847; 500 µg/$1,404; 5 mg/$2,807; 2 mg/$2,029
Neuroserpin Protein - 12.5% SDS-PAGE of human SERPINI1 stained with Coomassie Blue
Select
Wheat Germ Extract
GST
69.08 kDa
10 µg/$479; 25 µg/$670
Neuroserpin Protein
Select
E. coli
None
Biologically active
44.7 kDa
5 µg/$282; 100 µg/$957; 500 µg/$1,747
Select
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
44.8 kDa
5 µg/$268; 25 µg/$349
Select
Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
46 kDa
50 µg/$721
Select
Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
46 kDa
50 µg/$721
Viewing 1-6 of 6 product results


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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).