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Neuroserpin

serpin peptidase inhibitor, clade I (neuroserpin), member 1

Neuroserpin is a member of the serpin superfamily of serine proteinase inhibitors. The protein is primarily secreted by axons in the brain, and preferentially reacts with and inhibits tissue-type plasminogen activator. It is thought to play a role in the regulation of axonal growth and the development of synaptic plasticity. Mutations in this gene result in familial encephalopathy with neuroserpin inclusion bodies (FENIB), which is a dominantly inherited form of familial encephalopathy and epilepsy characterized by the accumulation of mutant neuroserpin polymers. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Gene Name: serpin peptidase inhibitor, clade I (neuroserpin), member 1
Synonyms: SERPINI1, Neuroserpin, Peptidase inhibitor 12, PI12, Serpin I1, PI-12, Protease inhibitor 12
Target Sequences: NM_005025 NP_005016.1 Q99574

Publications (1)

1
Stress-Induced Cellular Clearance Is Mediated by the SNARE Protein ykt6 and Disrupted by a-Synuclein. Leah K Cuddy, Willayat Y Wani, Martino L Morella, Caleb Pitcairn, Kotaro Tsutsumi, Kristina Fredriksen, Craig J Justman, Tom N Grammatopoulos, Nandkishore R Belur, Friederike Zunke, Aarthi Subramanian, Amira Affaneh, Peter T Lansbury Jr, Joseph R Mazzulli. Neuron. 2019 December;104:869-884.e11. [Full Text Article] [PubMed:31648898] [PMC:PMC6895429]

☰ Filters
Antibodies (48)
Proteins (6)
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Neuroserpin (57)
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Neuroserpin Antibody - Anti-SERPINI1 / Neuroserpin antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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Neuroserpin Mouse anti-Human Monoclonal (1D10) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
Neuroserpin Antibody - SERPINI1 antibody immunohistochemistry of formalin-fixed and paraffin-embedded human brain tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
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Neuroserpin Rabbit anti-Human Polyclonal (aa19-45) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
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Neuroserpin Rabbit anti-Human Polyclonal (aa19-45) (Biotin) Antibody
Human
ELISA, Flo, IF, IHC, WB
Biotin Conjugated
200 µl/$952
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Neuroserpin Rabbit anti-Human Polyclonal (aa19-45) (FITC) Antibody
Human
ELISA, Flo, ICC, IF, IHC, WB
FITC Conjugated
200 µl/$952
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Neuroserpin Rabbit anti-Human Polyclonal (aa19-45) (PE) Antibody
Human
ELISA, Flo, ICC, IF, IHC, WB
PE Conjugated
200 µl/$952
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Neuroserpin Rabbit anti-Human Polyclonal (aa19-45) (Azide-free) (HRP) Antibody
Human
ELISA, Flo, ICC, IF, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
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Neuroserpin Rabbit anti-Human Polyclonal (aa19-45) (APC) Antibody
Human
ELISA, Flo, ICC, IF, IHC, WB
APC Conjugated
200 µl/$952
Neuroserpin Antibody - Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Neuroscience
Neuroserpin Goat anti-Human Polyclonal (aa399-410) Antibody
Rabbit, Mouse, Dog, Rat, Hamster, Pig, Horse, Human, Monkey
IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$460
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Neuroserpin Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
100 µl/$412
Neuroserpin Antibody - Immunochemical staining of mouse Neuroserpin in mouse brain with rabbit polyclonal antibody at 1:5000 dilution, formalin-fixed paraffin embedded sections.
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Neuroserpin Rabbit anti-Mouse Polyclonal Antibody
Mouse
ELISA, IHC-P, IP, WB
Unconjugated
100 µl/$412
Neuroserpin ELISA Kit
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Development Kit
200 Wells
Human
63 - 4000 pg/ml
Colorimetric - 405nm (ABTS)
1 Test/$180
Neuroserpin ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$834
Neuroserpin Antibody - Immunohistochemistry - SERPINI1 Polyclonal Antibody
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Neuroserpin Rabbit anti-Mouse Polyclonal (aa181-410) Antibody
Mouse, Rat
IF, IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
Neuroserpin Antibody - Immunohistochemistry of paraffin-embedded human brain tissue at dilution of 1:100
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Neuroserpin Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
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Neuroserpin Rabbit anti-Mouse Polyclonal Antibody
Mouse
IHC, IHC-P
Unconjugated
100 µl/$412
Neuroserpin Antibody - Western Blot (non-reducing) of Neuroserpin antibody. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Neuroserpin Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
50 µg/$356; 100 µg/$396
Neuroserpin Antibody - Western Blot (non-reducing) of Neuroserpin antibody. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Neuroserpin Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
25 µg/$356; 50 µg/$396
Neuroserpin Antibody - Immunohistochemistry of paraffin-embedded Rat brain using SERPINI1 Polyclonal Antibody at dilution of 1:200 (40x lens).
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Neuroserpin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
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Neuroserpin Rat anti-Human Monoclonal (aa19-410) Antibody
Mouse, Human
ELISA, WB
Unconjugated
100 µg/$872
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Neuroserpin Sheep anti-Mouse Polyclonal Antibody
Mouse
ELISA, WB
Unconjugated
100 µg/$435; 1 mg/$586; 10 mg/$3,131
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Neuroserpin Sheep anti-Mouse Polyclonal (Biotin) Antibody
Mouse
ELISA, WB
Biotin Conjugated
100 µg/$468; 1 mg/$662; 10 mg/$3,367
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Neuroserpin Sheep anti-Mouse Polyclonal (FITC) Antibody
Mouse
ELISA, WB
FITC Conjugated
100 µg/$468; 1 mg/$662; 10 mg/$3,367
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Neuroserpin Sheep anti-Mouse Polyclonal Antibody
Mouse
ELISA, WB
Unconjugated
100 µl/$425; 1 ml/$568; 10 ml/$3,131
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Neuroserpin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µg/$357
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Neuroserpin Mouse anti-Human Monoclonal (Preservative Free) (08) Antibody
Human
ELISA, IHC-P
Unconjugated, Preservative Free
100 µl/$412
Viewing 1-25 of 57 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).