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Plays an important role in the process of myofiber differentiation and maturation. Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of proteins. Probably contributes to catalysis through recognition and positioning of the substrate and the ubiquitin-conjugating enzyme. During myogenesis, controls the ubiquitination and degradation of the specific pool of CTNNB1/beta-catenin located at the sarcolemma.
Gene Name: | neuralized E3 ubiquitin protein ligase 2 |
Synonyms: | NEURL2, C20orf163, Neuralized-like 2 (Drosophila), Neuralized-like 2, OZZ, Ozz-E3, Neuralized-like protein 2, DJ337O18.6 |
Target Sequences: | AW298115 Q9BR09 Q9BR09 |
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