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NEURL1 / NEURL
neuralized E3 ubiquitin protein ligase 1
Plays a role in hippocampal-dependent synaptic plasticity, learning and memory. Involved in the formation of spines and functional synaptic contacts by modulating the translational activity of the cytoplasmic polyadenylation element-binding protein CPEB3. Promotes ubiquitination of CPEB3, and hence induces CPEB3-dependent mRNA translation activation of glutamate receptor GRIA1 and GRIA2. Can function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1 (in vitro), thereby regulating the Notch pathway. Acts as a tumor suppressor; inhibits malignant cell transformation of medulloblastoma (MB) cells by inhibiting the Notch signaling pathway.
| Gene Name: | neuralized E3 ubiquitin protein ligase 1 |
| Synonyms: | NEURL1, H-neuralized 1, Neu, Neu-1, Neuralized-like (Drosophila), Neuralized-like protein 1A, NEURL, RNF67, RING finger protein 67, BA416N2.1, H-neu, Neuralized (Drosophila)-like, NEURL1A |
| Target Sequences: | NM_004210 NP_004201.3 O76050 |
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