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2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
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Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
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Tel: +1 (206) 374-1102
Fax: +1 (206) 577-4565
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NET1 / ARHGEF8
neuroepithelial cell transforming 1
NET1 is part of the family of Rho guanine nucleotide exchange factors. Members of this family activate Rho proteins by catalyzing the exchange of GDP for GTP. The protein encoded by this gene interacts with RhoA within the cell nucleus and may play a role in repairing DNA damage after ionizing radiation. Pseudogenes of this gene are located on the long arms of chromosomes 1, 7 and 18. Alternative splicing results in multiple transcript variants that encode different protein isoforms.
| Gene Name: | neuroepithelial cell transforming 1 |
| Synonyms: | NET1, ARHGEF8, NET1A, Proto-oncogene p65 Net1 |
| Target Sequences: | NM_005863 NP_005854.2 Q7Z628 |
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