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2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
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20700 44th Avenue W
Lynnwood, WA 98036
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NEP / DDR1
discoidin domain receptor tyrosine kinase 1
Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing (By similarity). Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11.
| Gene Name: | discoidin domain receptor tyrosine kinase 1 |
| Family/Subfamily: | Protein Kinase , DDR/TKT |
| Synonyms: | DDR1, Cell adhesion kinase, CD167, CD167a antigen, EDDR1, ENTRK4, Mammary carcinoma kinase 10, MCK10, NEP, PTK3, PTK3A, RTK6, Tyrosine-protein kinase CAK, CAK, DDR, Discoidin domain receptor 1, HGK2, MCK-10, NTRK4, Protein-tyrosine kinase 3A, Protein-tyrosine kinase RTK-6, TRK E, TRKE, Tyrosine kinase DDR |
| Target Sequences: | NM_013994 NP_054700.2 Q08345 |
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