NEK2

NIMA-related kinase 2

Protein kinase which is involved in the control of centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells. Regulates centrosome separation (essential for the formation of bipolar spindles and high-fidelity chromosome separation) by phosphorylating centrosomal proteins such as CROCC, CEP250 and NINL, resulting in their displacement from the centrosomes. Regulates kinetochore microtubule attachment stability in mitosis via phosphorylation of NDC80. Involved in regulation of mitotic checkpoint protein complex via phosphorylation of CDC20 and MAD2L1. Plays an active role in chromatin condensation during the first meiotic division through phosphorylation of HMGA2. Phosphorylates: PPP1CC; SGOL1; NECAB3 and NPM1. Essential for localization of MAD2L1 to kinetochore and MAPK1 and NPM1 to the centrosome. Isoform 1 phosphorylates and activates NEK11 in G1/S-arrested cells. Isoform 2, which is not present in the nucleolus, does not.

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Proteins (6)

Type

Over-Expression Lysate (2)

Recombinant (4)

Target

NEK2 (6)

Publications

No (5)

Yes (1)

Tag

GST, N-terminus (1)

His-T7 (3)

Myc-DDK (Flag) (2)

Species

Human (3)

Mouse (1)

Rat (1)

Source

293T Cells (1)

E. coli (3)

HEK 293 Cells (1)

Wheat Germ Extract (1)

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Human NEK2 Protein (Recombinant GST, N-terminus) (aa331-445) - LS-G59377

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Mouse NEK2 Protein (Recombinant His-T7) (aa148-397) - LS-G15902

Source:

E. coli

Tag:

His-T7

Molecular Weight:

32.7 kDa

Price:

10 µg/$279; 50 µg/$427; 100 µg/$682; 200 µg/$852; 1 mg/$1,950; 500 µg/$1,494; 5 mg/$2,983; 2 mg/$2,136

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Rat NEK2 Protein (Recombinant His-T7) (aa137-400) - LS-G15904

Source:

E. coli

Tag:

His-T7

Molecular Weight:

34.1 kDa

Price:

10 µg/$282; 50 µg/$450; 100 µg/$717; 200 µg/$897; 1 mg/$2,010; 500 µg/$1,547; 5 mg/$3,137; 2 mg/$2,198

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Human NEK2 Protein (Recombinant His-T7) (aa125-393) - LS-G25896

(4.0) Rating

(1) Publication(s)

Source:

E. coli

Tag:

His-T7

Molecular Weight:

35.0kd

Price:

10 µg/$276; 50 µg/$412; 100 µg/$657; 200 µg/$822; 1 mg/$1,905; 500 µg/$1,455; 5 mg/$2,871; 2 mg/$2,090

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Human NEK2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78756

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

51.6 kDa

Price:

20 µg/$150

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NEK2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G117943

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

51.6 kDa

Price:

100 µg/$494

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