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NEIL2
nei endonuclease VIII-like 2 (E. coli)
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Has DNA glycosylase activity towards 5-hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double-stranded DNA (DNA bubbles). Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
| Gene Name: | nei endonuclease VIII-like 2 (E. coli) |
| Synonyms: | NEIL2, Nei homolog 2, NEH2, Nei like 2, Nei like 2 (E. coli), DNA glycosylase/AP lyase Neil2, Endonuclease 8-like 2, Endonuclease VIII-like 2, Nei-like protein 2, NEI2 |
| Target Sequences: | Q969S2 Q969S2 |
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