NEI3 / NEIL3

nei endonuclease VIII-like 3 (E. coli)

DNA glycosylase which prefers single-stranded DNA (ssDNA), or partially ssDNA structures such as bubble and fork structures, to double-stranded DNA (dsDNA). In vitro, displays strong glycosylase activity towards the hydantoin lesions spiroiminodihydantoin (Sp) and guanidinohydantoin (Gh) in both ssDNA and dsDNA; also recognizes FapyA, FapyG, 5-OHU, 5-OHC, 5-OHMH, Tg and 8-oxoA lesions in ssDNA. No activity on 8-oxoG detected. Also shows weak DNA-(apurinic or apyrimidinic site) lyase activity. In vivo, appears to be the primary enzyme involved in removing Sp and Gh from ssDNA in neonatal tissues. Seems to be an important facilitator of cell proliferation in certain populations, for example neural stem/progenitor cells and tumor cells, suggesting a role in replication-associated DNA repair.

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ELISA Kits (6)

Type

Competitive EIA (1)

Custom (2)

Sandwich (3)

Target

NEI3 / NEIL3 (6)

Reactivity

Human (1)

Mouse (3)

Rat (1)

Format

96-Well Strip Plate (6)

Publications

No (6)

Sample Type

Cell Lysates (1)

Plasma (3)

Serum (3)

Tissue Homogenates (2)

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Mouse NEI3 / NEIL3 (Sandwich ELISA) ELISA Kit - LS-F33883

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.78 - 50 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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Human NEI3 / NEIL3 (Custom ELISA) ELISA Kit - LS-F19926

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Human

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

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Bovine NEI3 / NEIL3 (Custom ELISA) ELISA Kit - LS-F19927

Type:

Custom

Format:

96-Well Strip Plate

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

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Rat NEI3 / NEIL3 (Competitive EIA) ELISA Kit - LS-F38877

Type:

Competitive EIA

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

123.5 - 10000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$946

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Mouse NEI3 / NEIL3 (Sandwich ELISA) ELISA Kit - LS-F9410

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$923

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Mouse NEI3 / NEIL3 (Sandwich ELISA) ELISA Kit - LS-F12134

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.78 - 50 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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