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NEFH / NF-H

neurofilament, heavy polypeptide

Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the heavy neurofilament protein. This protein is commonly used as a biomarker of neuronal damage and susceptibility to amyotrophic lateral sclerosis (ALS) has been associated with mutations in this gene.

Gene Name: neurofilament, heavy polypeptide
Synonyms: NEFH, 200 kDa neurofilament protein, KIAA0845, NFH, NF-H
Target Sequences: NM_021076 NP_066554.2 P12036

Publications (3)

1
Human immunodeficiency virus (HIV)-induced neurotoxicity: roles for the NMDA receptor subtypes. O'Donnell LA, Agrawal A, Jordan-Sciutto KL, Dichter MA, Lynch DR, Kolson DL. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2006 26:981-90. [PubMed:16421318]
2
Caveolin-1 deficiency increases cerebral ischemic injury. Jasmin JF, Malhotra S, Singh Dhallu M, Mercier I, Rosenbaum DM, Lisanti MP. Circulation research. 2007 100:721-9. [PubMed:17293479]
3
Neurofilament protein levels: quantitative analysis in essential tremor cerebellar cortex. Louis ED, Ma K, Babij R, Corts E, Liem RK, Vonsattel JP, Faust PL. Neuroscience letters. 2012 518:49-54. (IHC, WB; Human) [PubMed:22561033] [PMC:PMC3364538]

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Proteins (5)
Over-Expression Lysate (2)
Recombinant (3)
NEFH / NF-H (5)
No (5)
10His-SUMO, N-terminus + Myc, C-terminus (1)
GST, N-terminus (1)
Myc-DDK (Flag) (3)
Human (4)
293T Cells (1)
E. coli (1)
HEK 293 Cells (2)
Wheat Germ Extract (1)
Purified (1)
NEFH / NF-H Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
10His-SUMO, N-terminus + Myc, C-terminus
1 mg/$1,355; 100 µg/$420; 20 µg/$323
NEFH / NF-H Protein - Purified recombinant protein NEFH was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
111.7 kDa
20 µg/$1,107
NEFH / NF-H Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
111.7 kDa
20 µg/$215
NEFH / NF-H Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
NEFH / NF-H Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
111.7 kDa
100 µg/$710
Viewing 1-5 of 5 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).