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NEDD4L / NEDD4-2
neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5. Promotes ubiquitination and degradation of SGK1 and TNK2.
| Gene Name: | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase |
| Synonyms: | NEDD4L, HNEDD4-2, KIAA0439, NEDD4-2, RSP5, NEDD4.2, NEDL3, Ubiquitin-protein ligase Rsp5 |
| Target Sequences: | AB007899 BAA23711.1 Q96PU5 |
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