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NEDD4L / NEDD4-2
neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5. Promotes ubiquitination and degradation of SGK1 and TNK2.
| Gene Name: | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase |
| Synonyms: | NEDD4L, HNEDD4-2, KIAA0439, NEDD4-2, RSP5, NEDD4.2, NEDL3, Ubiquitin-protein ligase Rsp5 |
| Target Sequences: | AB007899 BAA23711.1 Q96PU5 |
☰ Filters
Products
Antibodies
(29)
Proteins
(6)
Type
Over-Expression Lysate
(2)
Primary
(29)
Recombinant
(4)
Target
NEDD4L / NEDD4-2
(35)
Reactivity
Human
(24)
Mouse
(21)
Rat
(7)
Bat
(3)
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(3)
Chicken
(3)
Chimpanzee
(3)
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(3)
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(3)
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(3)
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(3)
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(3)
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(3)
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(3)
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(3)
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(3)
Application
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(9)
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(4)
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(23)
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(11)
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(3)
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(1)
Host
rabbit
(29)
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(3)
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IgG
(22)
Clonality
polyclonal pc
(29)
Format
APC Conjugated
(1)
Azide-free
(1)
Biotin Conjugated
(3)
FITC Conjugated
(3)
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(3)
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(1)
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(18)
Epitope
aa576-604
(7)
aa431-480
(4)
aa275-325
(2)
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(1)
aa225-275
(1)
aa425-475
(1)
Publications
No
(35)
Tag
GST
(2)
GST, N-terminus
(1)
Myc-DDK (Flag)
(3)
Species
Human
(5)
Source
293T Cells
(1)
HEK 293 Cells
(2)
Wheat Germ Extract
(3)
Purification
Purified
(2)
Wheat Germ Extract
GST
125.99 kDa
10 µg/$479; 25 µg/$670
NEDD4L / NEDD4-2 Rabbit anti-Human Polyclonal (aa275-325) Antibody
Mouse, Human
IHC, IHC-P
Unconjugated
50 µl/$460
NEDD4L / NEDD4-2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
NEDD4L / NEDD4-2 Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$286; 100 µl/$321
NEDD4L / NEDD4-2 Rabbit anti-Human Polyclonal (aa225-275) Antibody
Mouse, Human
IHC, IHC-P, IP, WB
Unconjugated
50 µl/$460
NEDD4L / NEDD4-2 Rabbit anti-Human Polyclonal (aa275-325) Antibody
Mouse, Human
IHC, IHC-P, IP, WB
Unconjugated
50 µl/$460
NEDD4L / NEDD4-2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$341
NEDD4L / NEDD4-2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
NEDD4L / NEDD4-2 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
NEDD4L / NEDD4-2 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
NEDD4L / NEDD4-2 Rabbit anti-Human Polyclonal (aa576-604) Antibody
Mouse, Human
ELISA, WB
Unconjugated
200 µl/$734
NEDD4L / NEDD4-2 Rabbit anti-Mouse Polyclonal (aa576-604) (Biotin) Antibody
Mouse
ELISA, WB
Biotin Conjugated
200 µl/$952
NEDD4L / NEDD4-2 Rabbit anti-Mouse Polyclonal (aa576-604) (FITC) Antibody
Mouse
ELISA, WB
FITC Conjugated
200 µl/$952
NEDD4L / NEDD4-2 Rabbit anti-Mouse Polyclonal (aa576-604) (APC) Antibody
Mouse
ELISA, WB
APC Conjugated
200 µl/$952
NEDD4L / NEDD4-2 Rabbit anti-Mouse Polyclonal (aa576-604) (PE) Antibody
Mouse
ELISA, WB
PE Conjugated
200 µl/$952
NEDD4L / NEDD4-2 Rabbit anti-Mouse Polyclonal (aa576-604) (Azide-free) (HRP) Antibody
Mouse
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
NEDD4L / NEDD4-2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
10 µg/$318; 100 µg/$470
NEDD4L / NEDD4-2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
50 µg/$294; 100 µg/$360
NEDD4L / NEDD4-2 Rabbit anti-Human Polyclonal (aa425-475) Antibody
Mouse, Human
IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
NEDD4L / NEDD4-2 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
NEDD4L / NEDD4-2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
100 µg/$357
NEDD4L / NEDD4-2 Rabbit anti-Human Polyclonal (Ser342) Antibody
Mouse, Rat, Human
WB
Unconjugated
100 µg/$357
NEDD4L / NEDD4-2 Rabbit anti-Human Polyclonal (aa431-480) Antibody
Human
WB
Unconjugated
100 µl/$424
NEDD4L / NEDD4-2 Rabbit anti-Human Polyclonal (aa431-480) (FITC) Antibody
Xenopus, Chicken, Bovine, Rabbit, Mouse, Dog, Guinea pig, Bat, Rat, Pig, Horse, Chimpanzee, Gibbon, Orangutan, Human, Monkey
WB
FITC Conjugated
100 µl/$469
NEDD4L / NEDD4-2 Rabbit anti-Human Polyclonal (aa576-604) Antibody
Mouse, Human
WB
Unconjugated
400 µl/$393
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of 35
product results
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