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NDP

Norrie disease (pseudoglioma)

Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and proliferation. Possible role in neuroectodermal cell-cell interaction.

Gene Name: Norrie disease (pseudoglioma)
Synonyms: NDP, FEVR, ND, Norrie disease (pseudoglioma), Norrie disease protein, Norrin, EVR2
Target Sequences: NM_000266 NP_000257.1 Q00604

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Antibodies (13)
Primary (13)
NDP (13)
Human (12)
Mouse (7)
Rat (3)
Monkey (1)
IHC (4)
IHC-P (2)
WB (8)
ELISA (4)
ICC (1)
Peptide-ELISA (1)
rabbit (12)
mouse (1)
IgG (10)
IgG1 (1)
monoclonal mc (1)
polyclonal pc (12)
Biotin Conjugated (1)
FITC Conjugated (1)
HRP Conjugated (1)
Preservative Free (1)
Unconjugated (10)
aa25-133 (1)
No (13)
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NDP Mouse anti-Human Monoclonal (aa25-133) Antibody
Mouse, Human
ELISA, WB
Unconjugated
100 µg/$884
NDP Antibody - Western blot analysis of extracts of various cell lines.
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NDP Rabbit anti-Human Polyclonal Antibody
Mouse, Human
WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
NDP Antibody - Immunocytochemistry of Norrin in Jurkat cells with Norrin antibody at 5 ug/ml.
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NDP Rabbit anti-Human Polyclonal Antibody
Human
ELISA, ICC, WB
Unconjugated
0.1 mg/$460
NDP Antibody - Immunohistochemistry image of paraffin-embedded human small intestine tissue at a dilution of 1:100
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NDP Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
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NDP Rabbit anti-Human Polyclonal (HRP) Antibody
Human
HRP Conjugated
50 µg/$294; 100 µg/$360
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NDP Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
Biotin Conjugated
50 µg/$294; 100 µg/$360
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NDP Rabbit anti-Human Polyclonal (FITC) Antibody
Human
FITC Conjugated
50 µg/$294; 100 µg/$360
NDP Antibody - 1:100 staining mouse brain tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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NDP Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human, Monkey
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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NDP Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
50 µl/$356; 100 µl/$461
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NDP Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, WB
Unconjugated
100 µg/$357
NDP Antibody - Immunochemical staining of mouse NDP in mouse kidney with rabbit polyclonal antibody at 1:1000 dilution, formalin-fixed paraffin embedded sections.
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NDP Rabbit anti-Mouse Polyclonal (Preservative Free) Antibody
Mouse
IHC-P, WB
Unconjugated, Preservative Free
100 µl/$412
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NDP Rabbit anti-Human Polyclonal Antibody
Rat, Human
IHC
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
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NDP Rabbit anti-Human Polyclonal Antibody
Mouse, Human
WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).