NCSTN / Nicastrin

nicastrin

NCSTN / Nicastrin is a type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Mutations in this gene are associated with familial acne inversa. A pseudogene of this gene is present on chromosome 21. Alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.

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Products

Proteins (11)

Type

Over-Expression Cell Culture Supernatant (1)

Over-Expression Lysate (2)

Recombinant (8)

Target

NCSTN / Nicastrin (11)

Publications

No (11)

Tag

Fc (1)

GST (1)

GST, N-terminus (1)

His (2)

His, N-Terminal (1)

His,C-terminus (1)

His-T7 (1)

Myc-DDK (Flag) (3)

Species

Human (7)

Mouse (2)

Rat (1)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (4)

Human Cells (2)

Wheat Germ Extract (2)

Purification

Purified (3)

Supernatant (1)

Low Endotoxin Level

Low endotoxin level (3)

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Human NCSTN / Nicastrin Protein (Recombinant GST, N-terminus) (aa16-115) - LS-G61974

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human NCSTN / Nicastrin Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67945

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

75.2 kDa

Price:

20 µg/$1,107

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Human NCSTN / Nicastrin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81044

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

78.41 kDa

Price:

20 µg/$215

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Human NCSTN / Nicastrin Protein (Over-Expression Cell Culture Supernatant His, N-Terminal) (Leu34-Cys669) - LS-G96946

Source:

HEK 293 Cells

Tag:

His, N-Terminal

Molecular Weight:

~71 kDa

Price:

200 µl/$283

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Human NCSTN / Nicastrin Protein (Recombinant His-T7) (aa420-655) - LS-G15015

Source:

E. coli

Tag:

His-T7

Molecular Weight:

30.4 kDa

Price:

10 µg/$282; 50 µg/$447; 100 µg/$715; 200 µg/$892; 1 mg/$2,005; 500 µg/$1,543; 5 mg/$3,123; 2 mg/$2,192

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Rat NCSTN / Nicastrin Protein (Recombinant His) (aa35-534) - LS-G25039

Source:

E. coli

Tag:

His

Molecular Weight:

59.1 kDa

Price:

10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204

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Human NCSTN / Nicastrin Protein (Recombinant GST) (Full Length) - LS-G32819

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

103.1 kDa

Price:

10 µg/$479; 25 µg/$670

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Human NCSTN / Nicastrin Protein (Recombinant His,C-terminus) (Met1-Glu669) - LS-G138428

Source:

HEK 293 Cells

Tag:

His,C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

72.4 kDa

Price:

50 µg/$854

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Mouse NCSTN / Nicastrin Protein (Recombinant His) (Met1-Gln668) - LS-G98222

Source:

Human Cells

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

73 kDa

Price:

100 µg/$843

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Mouse NCSTN / Nicastrin Protein (Recombinant Fc) (Met1-Glu668) - LS-G98225

Source:

Human Cells

Tag:

Fc

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

98.5 kDa

Price:

100 µg/$843

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NCSTN / Nicastrin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G113298

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

78.41 kDa

Price:

100 µg/$710

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