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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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NCSTN / Nicastrin

nicastrin

NCSTN / Nicastrin is a type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Mutations in this gene are associated with familial acne inversa. A pseudogene of this gene is present on chromosome 21. Alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.

Gene Name: nicastrin
Family/Subfamily: Protease
Synonyms: NCSTN, Anterior pharynx-defective 2, ATAG1874, KIAA0253, Nicastrin, APH2, RP11-517F10.1
Target Sequences: NM_015331 NP_056146.1 Q92542

Filtered By: None
Target
NCSTN / Nicastrin (45)
Reactivity
Human (34)
Mouse (10)
Rat (20)
Bat (1)
Bovine (1)
Chimpanzee (1)
Dog (1)
Horse (1)
Monkey (1)
Orangutan (1)
Pig (1)
Application
IHC (22)
IHC-P (3)
WB (36)
Flo (3)
ELISA (10)
ICC (4)
IF (4)
IP (2)
Peptide-ELISA (1)
Host
rabbit (42)
mouse (3)
Isotype
IgG (30)
IgG2b (1)
IgG2b,k (1)
Clonality
monoclonal mc (3)
polyclonal pc (42)
Format
APC (2)
APC Conjugated (2)
Biotin Conjugated (4)
Cy3 Conjugated (2)
Cy7 Conjugated (2)
FITC Conjugated (5)
HRP Conjugated (2)
PE Conjugated (3)
Unconjugated (25)
Epitope
aa35-534 (10)
aa420-655 (10)
C-Terminus (3)
Internal (1)
aa34-153 (1)
aa72-88 (1)
aa99-133 (1)
Publications
No (45)
Showing 1-25 of 45 results

NCSTN / Nicastrin Antibody (Internal) IHC-plus™ LS-B1380
Rabbit Polyclonal (IgG) to Human NCSTN / Nicastrin
Mouse, Rat, Human
IF IHC IHC-P WB
Unconjugated
50µg 1mg/ml  $425.00
Anti-NCSTN / Nicastrin antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Immunofluorescence of Nicastrin in Human Brain cells with Nicastrin antibody at 20 ug/ml.
Anti-NCSTN / Nicastrin antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Immunofluorescence of Nicastrin in Human Brain cells with Nicastrin antibody at 20 ug/ml.

NCSTN / Nicastrin Antibody (C-Terminus) IHC-plus™ LS-B530
Rabbit Polyclonal (IgG) to Human NCSTN / Nicastrin
Mouse, Rat, Human
IF IHC IHC-P WB
Unconjugated
50µg 1mg/ml  $425.00
Anti-NCSTN / Nicastrin antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Immunofluorescence of Nicastrin in Human Brain cells with Nicastrin antibody at 20 ug/ml.
Anti-NCSTN / Nicastrin antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Immunofluorescence of Nicastrin in Human Brain cells with Nicastrin antibody at 20 ug/ml.

NCSTN / Nicastrin Antibody LS-C401888
Rabbit Polyclonal (IgG) to Human NCSTN / Nicastrin
Mouse, Rat, Human
ELISA IHC WB
Unconjugated
20µl  $205.00; 60µl  $235.00; 120µl  $295.00; 200µl  $395.00
Immunohistochemistry of Human liver cancer using NCSTN Polyclonal Antibody at dilution of 1:50.
Immunohistochemistry of Human prostate cancer using NCSTN Polyclonal Antibody at dilution of 1:50.
Immunohistochemistry of Human liver cancer using NCSTN Polyclonal Antibody at dilution of 1:50.
Immunohistochemistry of Human prostate cancer using NCSTN Polyclonal Antibody at dilution of 1:50.

NCSTN / Nicastrin Antibody (C-Terminus) LS-C152950
Mouse Monoclonal (IgG2b) to Mouse NCSTN / Nicastrin
Mouse, Rat, Human
ICC IP WB
Unconjugated
100µl  $455.00

NCSTN / Nicastrin Antibody LS-C488469
Rabbit Polyclonal to Mouse NCSTN / Nicastrin
Mouse
ELISA IHC IHC-P
Unconjugated
50µl  $255.00; 100µl  $305.00; 200µl  $355.00

NCSTN / Nicastrin Antibody LS-C660342
Rabbit Polyclonal (IgG) to Human NCSTN / Nicastrin
Human
ELISA IF WB
Unconjugated
100µg  $405.00

NCSTN / Nicastrin Antibody LS-C488463
Rabbit Polyclonal to Human NCSTN / Nicastrin
Human
ICC IF
Unconjugated
50µl  $275.00; 100µl  $355.00

NCSTN / Nicastrin Antibody (aa34-153) LS-C131051
Mouse Monoclonal (IgG2b,k) to Human NCSTN / Nicastrin
Human
ELISA WB
Unconjugated
100µl  $475.00

NCSTN / Nicastrin Antibody (aa420-655) LS-C295627
Rabbit Polyclonal (IgG) to Human NCSTN / Nicastrin
Human
IHC WB
Unconjugated
20µl 0.5mg/ml  $205.00; 100µl 0.5mg/ml  $255.00; 200µl 0.5mg/ml  $305.00; 1ml 0.5mg/ml  $530.00; 10ml 0.5mg/ml  $2,100.00
Western blot of recombinant NCSTN / Nicastrin.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Western blot of recombinant NCSTN / Nicastrin.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

NCSTN / Nicastrin Antibody (aa420-655, HRP) LS-C711798
Rabbit Polyclonal (IgG) to Human NCSTN / Nicastrin
Human
IHC WB
HRP Conjugated
20µl  $215.00; 100µl  $285.00; 200µl  $345.00; 1ml  $680.00; 10ml  $2,730.00
Western blot of recombinant NCSTN / Nicastrin.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Western blot of recombinant NCSTN / Nicastrin.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

NCSTN / Nicastrin Antibody (aa420-655, Biotin) LS-C687357
Rabbit Polyclonal (IgG) to Human NCSTN / Nicastrin
Human
IHC WB
Biotin Conjugated
20µl  $205.00; 100µl  $265.00; 200µl  $315.00; 1ml  $575.00; 10ml  $2,310.00
Western blot of recombinant NCSTN / Nicastrin.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Western blot of recombinant NCSTN / Nicastrin.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

NCSTN / Nicastrin Antibody (aa420-655, FITC) LS-C694178
Rabbit Polyclonal (IgG) to Human NCSTN / Nicastrin
Human
IHC WB
FITC Conjugated
20µl  $215.00; 100µl  $275.00; 200µl  $325.00; 1ml  $635.00; 10ml  $2,520.00
Western blot of recombinant NCSTN / Nicastrin.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Western blot of recombinant NCSTN / Nicastrin.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

NCSTN / Nicastrin Antibody (aa420-655, Cy3) LS-C702775
Rabbit Polyclonal (IgG) to Human NCSTN / Nicastrin
Human
IHC WB
Cy3 Conjugated
20µl  $245.00; 100µl  $355.00; 200µl  $445.00; 1ml  $1,050.00; 10ml  $4,200.00
Western blot of recombinant NCSTN / Nicastrin.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Western blot of recombinant NCSTN / Nicastrin.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

NCSTN / Nicastrin Antibody (aa420-655, APC) LS-C717970
Rabbit Polyclonal (IgG) to Human NCSTN / Nicastrin
Human
IHC WB
APC Conjugated
20µl  $225.00; 100µl  $305.00; 200µl  $375.00; 1ml  $785.00; 10ml  $6,255.00
Western blot of recombinant NCSTN / Nicastrin.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Western blot of recombinant NCSTN / Nicastrin.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

NCSTN / Nicastrin Antibody (aa420-655, PE) LS-C725860
Rabbit Polyclonal (IgG) to Human NCSTN / Nicastrin
Human
IHC WB
PE Conjugated
20µl  $215.00; 100µl  $275.00; 200µl  $325.00; 1ml  $635.00; 10ml  $2,520.00
Western blot of recombinant NCSTN / Nicastrin.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Western blot of recombinant NCSTN / Nicastrin.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

NCSTN / Nicastrin Antibody (aa420-655, APC, Cy7) LS-C734807
Rabbit Polyclonal (IgG) to Human NCSTN / Nicastrin
Human
IHC WB
APC, Cy7 Conjugated
20µl  $285.00; 100µl  $455.00; 200µl  $635.00; 1ml  $1,575.00; 10ml  $6,300.00
Western blot of recombinant NCSTN / Nicastrin.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Western blot of recombinant NCSTN / Nicastrin.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

NCSTN / Nicastrin Antibody LS-C192373
Rabbit Polyclonal to Human NCSTN / Nicastrin
Mouse, Rat, Human
IHC WB
Unconjugated
100µl  $385.00
Western blot of NCSTN pAb in extracts from mouse brain tissue and C6 cells.
Western blot of NCSTN pAb in extracts from mouse brain tissue and C6 cells.

NCSTN / Nicastrin Antibody LS-C405202
Rabbit Polyclonal (IgG) to Human NCSTN / Nicastrin
Mouse, Rat, Human
ELISA IHC
Unconjugated
20µl  $205.00; 60µl  $235.00; 120µl  $295.00; 200µl  $395.00
Immunohistochemistry of Human brain using NCSTN Polyclonal Antibody at dilution of 1:50.
Immunohistochemistry of Human brain using NCSTN Polyclonal Antibody at dilution of 1:50.
Immunohistochemistry of Human brain using NCSTN Polyclonal Antibody at dilution of 1:50.
Immunohistochemistry of Human brain using NCSTN Polyclonal Antibody at dilution of 1:50.

NCSTN / Nicastrin Antibody (C-Terminus) LS-C25766
Rabbit Polyclonal (IgG) to Human NCSTN / Nicastrin
Human
ELISA WB
Unconjugated
100µl  $530.00

NCSTN / Nicastrin Antibody LS-C488472
Rabbit Polyclonal to Human NCSTN / Nicastrin
Human
ELISA WB
Unconjugated
50µl  $255.00; 100µl  $305.00; 200µl  $355.00

NCSTN / Nicastrin Antibody (aa35-534) LS-C374626
Rabbit Polyclonal (IgG) to Rat NCSTN / Nicastrin
Rat
IHC WB
Unconjugated
20µl 0.5mg/ml  $205.00; 100µl 0.5mg/ml  $265.00; 200µl 0.5mg/ml  $315.00; 1ml 0.5mg/ml  $575.00; 10ml 0.5mg/ml  $2,280.00
Western blot of NCSTN / Nicastrin antibody.
Western blot of NCSTN / Nicastrin antibody.

NCSTN / Nicastrin Antibody LS-C488466
Rabbit Polyclonal to Human NCSTN / Nicastrin
Human
IP WB
Unconjugated
50µl  $275.00; 100µl  $355.00

NCSTN / Nicastrin Antibody (aa99-133) LS-C392706
Rabbit Polyclonal to Human NCSTN / Nicastrin
Rat, Human
Peptide-ELISA WB
Unconjugated
50µl  $205.00; 200µl  $305.00
All lanes: Anti-NCSTN Antibody (N-Term) at 1:8000 dilution. Lane 1: HL-60 whole cell lysates. Lane 2: HeLa whole cell lysates. Lane 3: C6 whole cell lysates Lysates/proteins at 20 ug per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1:10000 dilution. Predicted band size: 78 kDa. Blocking/Dilution buffer: 5% NFDM/TBST.
All lanes: Anti-NCSTN Antibody (N-Term) at 1:2000 dilution. Lane 1: Jurkat whole cell lysates. Lane 2: A431 whole cell lysates Lysates/proteins at 20 ug per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1:10000 dilution. Predicted band size: 78 kDa. Blocking/Dilution buffer: 5% NFDM/TBST.
All lanes: Anti-NCSTN Antibody (N-Term) at 1:8000 dilution. Lane 1: HL-60 whole cell lysates. Lane 2: HeLa whole cell lysates. Lane 3: C6 whole cell lysates Lysates/proteins at 20 ug per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1:10000 dilution. Predicted band size: 78 kDa. Blocking/Dilution buffer: 5% NFDM/TBST.
All lanes: Anti-NCSTN Antibody (N-Term) at 1:2000 dilution. Lane 1: Jurkat whole cell lysates. Lane 2: A431 whole cell lysates Lysates/proteins at 20 ug per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1:10000 dilution. Predicted band size: 78 kDa. Blocking/Dilution buffer: 5% NFDM/TBST.

NCSTN / Nicastrin Antibody LS-C488467
Mouse Monoclonal to Human NCSTN / Nicastrin
Human
ELISA
Unconjugated
50µl  $255.00; 100µl  $305.00; 200µl  $355.00

NCSTN / Nicastrin Antibody LS-C488468
Rabbit Polyclonal to Human NCSTN / Nicastrin
Human
Flo
Unconjugated
50µl  $275.00; 100µl  $355.00
Showing 1-25 of 45 results

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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