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Transcriptional corepressor. Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 5 have different affinities for different nuclear receptors. Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival.
Gene Name: | nuclear receptor corepressor 2 |
Synonyms: | NCOR2, CTG26, Nuclear receptor corepressor 2, SMAP270, SMRT, SMRTE, TRAC, N-CoR2, TNRC14, TRAC-1, TRAC1, CTG repeat protein 26, SMRTE-tau, T3 receptor-associating factor |
Target Sequences: | NM_006312 NP_006303.4 Q9Y618 |
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