NCOA2 / TIF2

nuclear receptor coactivator 2

The NCOA2 gene encodes nuclear receptor coactivator 2, which aids in the function of nuclear hormone receptors. Nuclear hormone receptors are conditional transcription factors that play important roles in various aspects of cell growth, development, and homeostasis by controlling expression of specific genes. Members of the nuclear hormone receptor superfamily, which includes the 5 steroid receptors and class II nuclear receptors (see below), are structurally characterized by 3 distinct domains: an N-terminal transcriptional activation domain, a central DNA-binding domain, and a C-terminal hormone-binding domain. Before the binding of hormone, steroid receptors, which are sometimes called class I of the nuclear hormone receptor family, remain inactive in a complex with heat-shock protein-90 (MIM 140571) and other stress family proteins. Binding of hormone induces critical conformational changes in steroid receptors that cause them to dissociate from the inhibitory complex, bind as homodimers to specific DNA enhancer elements associated with target genes, and modulate that gene's transcription. After binding to enhancer elements, transcription factors require transcriptional coactivator proteins to mediate their stimulation of transcription initiation (Hong et al., 1997 [PubMed 9111344]).

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Proteins (3)

Type

Over-Expression Lysate (2)

Recombinant (1)

Target

NCOA2 / TIF2 (3)

Publications

No (3)

Tag

GST, N-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (2)

Source

293T Cells (1)

HEK 293 Cells (1)

Wheat Germ Extract (1)

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Human NCOA2 / TIF2 Protein (Recombinant GST, N-terminus) (aa1365-1464) - LS-G61534

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human NCOA2 / TIF2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G86792

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

159 kDa

Price:

20 µg/$215

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NCOA2 / TIF2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100843

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

159 kDa

Price:

100 µg/$710

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