NCOA1 / SRC-1

nuclear receptor coactivator 1

Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3.

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ELISA Kits (5)

Type

Custom (3)

Sandwich (2)

Target

NCOA1 / SRC-1 (5)

Reactivity

Human (2)

Mouse (2)

Pig (1)

Format

96-Well Strip Plate (5)

Publications

No (5)

Sample Type

Plasma (2)

Serum (2)

Tissue Homogenates (2)

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Human NCOA1 / SRC-1 (Sandwich ELISA) ELISA Kit - LS-F34973

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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Mouse NCOA1 / SRC-1 (Custom ELISA) ELISA Kit - LS-F14332

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Mouse

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

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Human NCOA1 / SRC-1 (Custom ELISA) ELISA Kit - LS-F14333

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Human

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

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Pig NCOA1 / SRC-1 (Custom ELISA) ELISA Kit - LS-F14334

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Pig

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

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Mouse NCOA1 / SRC-1 (Sandwich ELISA) ELISA Kit - LS-F56357

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

15.625 - 1000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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