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NCL / Nucleolin

nucleolin

Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats.

Gene Name:	nucleolin
Synonyms:	NCL, Nucleolin, C23, Protein C23
Target Sequences:	NM_005381 NP_005372.2 P19338

Publications (11)

Nucleolin is one component of the B cell-specific transcription factor and switch region binding protein, LR1. Hanakahi LA, Dempsey LA, Li MJ, Maizels N. Proceedings of the National Academy of Sciences of the United States of America. 1997 94:3605-10. (ICC, WB; Human) [PubMed:9108024] [PMC:PMC20487]

Recognition and binding of the human selenocysteine insertion sequence by nucleolin. Wu R, Shen Q, Newburger PE. Journal of cellular biochemistry. 2000 77:507-16. (WB; Human) [PubMed:10760958]

Up-regulation of the KLF2 transcription factor by fluid shear stress requires nucleolin. Huddleson JP, Ahmad N, Lingrel JB. The Journal of biological chemistry. 2006 281:15121-8. [PubMed:16571724]

Identification of novel proteins associated with both alpha-synuclein and DJ-1. Jin J, Li GJ, Davis J, Zhu D, Wang Y, Pan C, Zhang J. Molecular & cellular proteomics : MCP. 2007 6:845-59. [PubMed:16854843]

Selenoprotein H is a nucleolar thioredoxin-like protein with a unique expression pattern. Novoselov SV, Kryukov GV, Xu XM, Carlson BA, Hatfield DL, Gladyshev VN. The Journal of biological chemistry. 2007 282:11960-8. [PubMed:17337453]

Identification and characterization of nucleolin as a c-myc G-quadruplex-binding protein. Gonzlez V, Guo K, Hurley L, Sun D. The Journal of biological chemistry. 2009 284:23622-35. [PubMed:19581307] [PMC:PMC2749137]

Anticancer activity of CX-3543: a direct inhibitor of rRNA biogenesis. Drygin D, Siddiqui-Jain A, O'Brien S, Schwaebe M, Lin A, Bliesath J, Ho CB, Proffitt C, Trent K, Whitten JP, Lim JK, Von Hoff D, Anderes K, Rice WG. Cancer research. 2009 69:7653-61. [PubMed:19738048]

Role of N-end rule ubiquitin ligases UBR1 and UBR2 in regulating the leucine-mTOR signaling pathway. Kume K, Iizumi Y, Shimada M, Ito Y, Kishi T, Yamaguchi Y, Handa H. Genes to cells : devoted to molecular & cellular mechanisms. 2010 15:339-49. [PubMed:20298436]

Nucleolin level in plant root meristematic cells under chilling stress and recovery. Stpiski D. Micron (Oxford, England : 1993). 2012 43:870-5. (Plant) [PubMed:22483616]

Identification and characterization of nucleolin as a COUP-TFII coactivator of retinoic acid receptor transcription in breast cancer cells. Litchfield LM, Riggs KA, Hockenberry AM, Oliver LD, Barnhart KG, Cai J, Pierce WM, Ivanova MM, Bates PJ, Appana SN, Datta S, Kulesza P, McBryan J, Young LS, Klinge CM. PloS one. 2012 7:e38278. (ICC; Human) [PubMed:22693611] [PMC:PMC3365040]

Autocrine IL-8 promotes F-actin polymerization and mediate mesenchymal transition via ELMO1-NF-?B-Snail signaling in glioma. Zhang B, Shi L, Lu S, Sun X, Liu Y, Li H, Wang X, Zhao C, Zhang H, Wang Y. Cancer biology & therapy. 2015 16:898-911. (IHC, WB; Human) [Full Text Article] [PubMed:25870011] [PMC:PMC4623112]

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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