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NCF1 / p47phox / p47 phox

neutrophil cytosolic factor 1

NCF1 encodes neutrophil cytosolic factor 1, the 47-kilodalton cytosolic subunit of the multi-protein complex known as NADPH oxidase found in neutrophils. This oxidase produces a burst of superoxide which is delivered to the lumen of the neutrophil phagosome. Mutations in NCF1, as well as in other NADPH oxidase subunits, can result in chronic granulomatous disease.

Gene Name: neutrophil cytosolic factor 1
Synonyms: NCF1, NCF1A, Neutrophil cytosolic factor 1, NCF-47K, Nox organizer 2, NOXO2, p47-phox, p47phox, SH3PXD1A, NADPH oxidase organizer 2, NCF-1, Neutrophil cytosol factor 1, Nox-organizing protein 2
Target Sequences: NM_000265 NP_000256.4 P14598

Publications (2)

1
NADPH oxidase expression in active multiple sclerosis lesions in relation to oxidative tissue damage and mitochondrial injury. Fischer MT, Sharma R, Lim JL, Haider L, Frischer JM, Drexhage J, Mahad D, Bradl M, van Horssen J, Lassmann H. Brain : a journal of neurology. 2012 135:886-99. (IHC-P; Human) [Full Text Article] [PubMed:22366799] [PMC:PMC3286337] Related Antibodies: LS-B2365.
2
Characterization of the inflammatory response to solid cancer metastases in the human brain. Berghoff AS, Lassmann H, Preusser M, H[Character f6]ftberger R. Clinical & experimental metastasis. 2013 Jan;30:69-81. [Full Text Article] [PubMed:22752508] Related Antibodies: LS-B2365.

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Proteins (8)
Over-Expression Lysate (2)
Recombinant (6)
NCF1 / p47phox / p47 phox (8)
No (8)
6His, C-terminus (1)
His (1)
His, C-Terminal (1)
His, N-Terminal (1)
His-T7 (1)
Myc-DDK (Flag) (3)
Human (7)
293T Cells (1)
E. coli (5)
HEK 293 Cells (2)
Purified (1)
Low endotoxin level (2)
NCF1 / p47phox / p47 phox Protein
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E. coli
His
50 µg/$411; 250 µg/$769; 10 µg/$276; 20 µg/$332; 100 µg/$544; 500 µg/$985
NCF1 / p47phox / p47 phox Protein - Purified recombinant protein NCF1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
44.5 kDa
20 µg/$1,107
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293T Cells
Myc-DDK (Flag)
44.5 kDa
20 µg/$150
NCF1 / p47phox / p47 phox Protein - Recombinant  Neutrophil Cytosolic Factor 1 By SDS-PAGE
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E. coli
His-T7
48.4 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
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E. coli
His, C-Terminal
Less than 1.0 EU/µg protein (determined by LAL method).
45.6kD
10 µg/$321; 50 µg/$534; 500 µg/$1,680; 1 mg/$2,353
NCF1 / p47phox / p47 phox Protein
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E. coli
His, N-Terminal
44.5 kDa
50 µg/$419
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E. coli
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
45.6 kDa
10 µg/$317; 50 µg/$524
NCF1 / p47phox / p47 phox Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
44.5 kDa
100 µg/$494
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).