NAR / CPSF4

cleavage and polyadenylation specific factor 4, 30kDa

Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage and polyadenylation specific factor 4, an essential component of the 3' end processing machinery of cellular pre-mRNAs. In influenza virus-infected cells, the NS1 protein is physically associated with cleavage and polyadenylation specific factor 4, 30kD subunit. Binding of the NS1 protein to the 30 kDa protein in vitro prevents CPSF binding to the RNA substrate and inhibits 3' end cleavage and polyadenylation of host pre-mRNAs. Thus the NS1 protein selectively inhibits the nuclear export of cellular, and not viral, mRNAs. Multiple alternatively spliced transcript variants that encode different isoforms have been described for this gene.

☰ Filters

Products

Proteins (9)

Type

Over-Expression Lysate (5)

Recombinant (4)

Target

NAR / CPSF4 (9)

Publications

No (9)

Tag

GST (1)

GST, N-terminus (1)

GST, N-terminus + His, C-terminus (1)

His (1)

Myc-DDK (Flag) (5)

Species

Human (7)

Source

293T Cells (3)

E. coli (3)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (3)

Select

NAR / CPSF4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G115120

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

30.1 kDa

Price:

100 µg/$494

Select

NAR / CPSF4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G119752

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

27.4 kDa

Price:

100 µg/$494

Select

Human NAR / CPSF4 Protein (Recombinant GST, N-terminus + His, C-terminus) - LS-G144851

Source:

E. coli

Tag:

GST, N-terminus + His, C-terminus

Molecular Weight:

53.4 kDa

Price:

50 µg/$419

Select

Human NAR / CPSF4 Protein (Recombinant His) - LS-G2239

Source:

E. coli

Tag:

His

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

Select

Human NAR / CPSF4 Protein (Recombinant GST) (Full Length) - LS-G32381

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

52.58 kDa

Price:

2 µg/$439

Select

Human NAR / CPSF4 Protein (Recombinant GST, N-terminus) (aa1-244) - LS-G56178

Source:

E. coli

Tag:

GST, N-terminus

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

Select

Human NAR / CPSF4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G86155

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

27.4 kDa

Price:

20 µg/$150

Select

Human NAR / CPSF4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G86156

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

30.1 kDa

Price:

20 µg/$150

Select

Human NAR / CPSF4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G86157

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

30.1 kDa

Price:

20 µg/$150

Viewing 1-9 of 9 product results

(0) Selected Add Selected To Cart Compare Selected Email Selected Clear Selected Top Of Search

---

Filtered By:

Products: Proteins

Clear Filters

If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.