NANOG

Nanog homeobox

Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3'. Able to autorepress its expression in differentiating (ES) cells: binds to its own promoter following interaction with ZNF281/ZFP281, leading to recruitment of the NuRD complex and subsequent repression of expression. When overexpressed, promotes cells to enter into S phase and proliferation.

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Products

Proteins (15)

Type

Over-Expression Cell Culture Supernatant (1)

Over-Expression Lysate (3)

Recombinant (11)

Target

NANOG (15)

Publications

No (15)

Tag

6His, N-terminus (2)

6His-SUMO, N-terminus (1)

GST, N-terminus (2)

His (1)

His, N-Terminal (2)

His-GST (1)

Myc-DDK (Flag) (2)

Tat (1)

Species

Human (12)

Mouse (2)

Source

293T Cells (1)

E. coli (8)

HEK 293 Cells (3)

Wheat Germ Extract (2)

Yeast (1)

Purification

Purified (7)

Low Endotoxin Level

Low endotoxin level (2)

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Human NANOG Protein (Recombinant GST, N-terminus) (aa98-195) - LS-G63207

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human NANOG Protein (Recombinant 6His-SUMO, N-terminus) (aa1-305) - LS-G56988

Source:

E. coli

Tag:

6His-SUMO, N-terminus

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human NANOG Protein (Recombinant 6His, N-terminus) (aa1-305) - LS-G57367

Source:

Yeast

Tag:

6His, N-terminus

Price:

100 µg/$570; 20 µg/$395; 1 mg/$1,973

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Human NANOG Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G84135

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

34.4 kDa

Price:

20 µg/$150

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Human NANOG Protein (Recombinant 6His, N-terminus) (Ser2-Val305) - LS-G26408

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

36.8 kDa

Price:

10 µg/$265; 50 µg/$315; 100 µg/$365

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Human NANOG Protein (Recombinant His-GST) (aa1-305) - LS-G26047

Source:

E. coli

Tag:

His-GST

Molecular Weight:

64.6 kDa

Price:

10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204

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Human NANOG Protein (Recombinant GST, N-terminus) (Full Length) - LS-G135960

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Molecular Weight:

61 kDa

Price:

2 µg/$439

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Mouse NANOG Protein (Over-Expression Lysate His, N-Terminal) (Ser2-Ile305) - LS-G136117

Source:

HEK 293 Cells

Tag:

His, N-Terminal

Molecular Weight:

~34 kDa

Price:

100 µg/$298

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Mouse NANOG Protein (Over-Expression Cell Culture Supernatant His, N-Terminal) (Ser2-Ile305) - LS-G136118

Source:

HEK 293 Cells

Tag:

His, N-Terminal

Molecular Weight:

~34 kDa

Price:

200 µl/$283

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NANOG Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G109720

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

34.4 kDa

Price:

100 µg/$494

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Human NANOG Protein (Recombinant) - LS-G1367

Source:

E. coli

Tag:

None

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

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Human NANOG Protein (Recombinant) - LS-G2431

Source:

E. coli

Tag:

None

Price:

20 µg/$361; 100 µg/$739; 4 µg/$261

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Human NANOG Protein (Recombinant His) - LS-G1349

Source:

E. coli

Tag:

His

Price:

50 µg/$411; 250 µg/$985; 10 µg/$276

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Human NANOG Protein (Recombinant Tat) - LS-G94

Source:

E. coli

Tag:

Tat

Endotoxin Level:

Less than 0.1 ng/µg of protein (less than 1EU/µg).

Molecular Weight:

36.2 kDa

Price:

5 µg/$268; 20 µg/$349

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Human NANOG Protein (Recombinant) - LS-G92

Source:

E. coli

Tag:

None

Endotoxin Level:

Less than 0.1 ng/µg of protein (less than 1EU/µg).

Molecular Weight:

34.5 kDa

Price:

5 µg/$268; 20 µg/$349

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