NALP3 / NLRP3

NLR family, pyrin domain containing 3

NALP3 / NLRP3 is a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid.

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Products

ELISA Kits (8)

Type

Sandwich (7)

Sandwich CLIA (1)

Target

NALP3 / NLRP3 (8)

Reactivity

Human (4)

Mouse (2)

Rat (1)

Bovine (1)

Product Group

Coronavirus Detection (8)

Cytokine Release Syndrome (8)

ELISA Kits for Cytokine Release Syndrome Targets (8)

Format

96-Well Strip Plate (8)

Publications

No (6)

Yes (2)

Sample Type

Cell Culture Supernatants (1)

Cell Lysates (3)

Plasma (5)

Serum (5)

Tissue Homogenates (6)

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Mouse NALP3 / NLRP3 (Sandwich ELISA) ELISA Kit - LS-F32087

(4.0) Rating

(1) Publication(s)

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$768

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Human NALP3 / NLRP3 (Sandwich ELISA) ELISA Kit - LS-F31954

(4.0) Rating

(1) Publication(s)

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.781 - 50 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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Mouse NALP3 / NLRP3 (Sandwich ELISA) ELISA Kit - LS-F17336

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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Bovine NALP3 / NLRP3 (Sandwich ELISA) ELISA Kit - LS-F17338

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Bovine

Range:

0.78 - 50 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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Human NALP3 / NLRP3 (Sandwich ELISA) ELISA Kit - LS-F17337

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$783

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Human NALP3 / NLRP3 (Sandwich ELISA) ELISA Kit - LS-F39626

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$834

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Human NALP3 / NLRP3 (CLIA) ELISA Kit - LS-F38859

Type:

Sandwich CLIA

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

68.6 - 50000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$968

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Rat NALP3 / NLRP3 (Sandwich ELISA) ELISA Kit - LS-F39627

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$893

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