NAK / TBK1

TANK-binding kinase 1

Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents. Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNA and IFNB. In order to establish such an antiviral state, TBK1 form several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules including FADD, TRADD, MAVS, AZI2, TANK or TBKBP1/SINTBAD can be recruited to the TBK1-containing-complexes. Under particular conditions, functions as a NF-kappa-B effector by phosphorylating NF-kappa-B inhibitor alpha/NFKBIA, IKBKB or RELA to translocate NF-Kappa-B to the nucleus. Restricts bacterial proliferation by phosphorylating the autophagy receptor OPTN/Optineurin on 'Ser-177', thus enhancing LC3 binding affinity and antibacterial autophagy. Phosphorylates and activates AKT1. Seems to play a role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, wich leads to a negative impact on insulin sensitivity. Attenuates retroviral budding by phosphorylating the endosomal sorting complex required for transport-I (ESCRT-I) subunit VPS37C. Phosphorylates Borna disease virus (BDV) P protein.

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Proteins (6)

Type

Over-Expression Lysate (2)

Recombinant (4)

Target

NAK / TBK1 (6)

Publications

No (6)

Tag

GST (1)

GST, N-terminus (1)

His-S (1)

Myc-DDK (Flag) (3)

Species

Human (5)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human NAK / TBK1 Protein (Recombinant GST, N-terminus) (aa630-729) - LS-G62297

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human NAK / TBK1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G87375

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

83.5 kDa

Price:

20 µg/$150

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NAK / TBK1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G114379

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

83.5 kDa

Price:

100 µg/$494

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Human NAK / TBK1 Protein (Recombinant His-S) (aa9-310) - LS-G25837

Source:

E. coli

Tag:

His-S

Molecular Weight:

37.9 kDa

Price:

10 µg/$276; 50 µg/$412; 100 µg/$657; 200 µg/$822; 1 mg/$1,905; 500 µg/$1,455; 5 mg/$2,871; 2 mg/$2,090

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Human NAK / TBK1 Protein (Recombinant GST) (Full Length) - LS-G33412

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

110 kDa

Price:

2 µg/$439

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Human NAK / TBK1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G70537

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

83.5 kDa

Price:

20 µg/$1,107

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